Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
OXT(20-28) [extracellular region]
Stable Identifier
R-HSA-388430
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Oxytocin, RecName: Full=Oxytocin-neurophysin 1; Short=OT-NPI; Contains: RecName: Full=Oxytocin; AltName: Full=Ocytocin; Contains: RecName: Full=Neurophysin 1; Flags: Precursor;
GN Name=OXT; Synonyms=OT;
OS Homo sapiens, NEU1_HUMAN, OXT
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Vasopressin-like receptors (Homo sapiens)
Oxytocin receptor bind oxytocin (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
OXTR:OXT(20-28) [plasma membrane] (Homo sapiens)
OXT(20-28) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01178 OXT
Gene Names
OXT, OT
Chain
signal peptide:1-19, peptide:20-28, chain:32-125
Reference Genes
BioGPS Gene:5020 OXT
COSMIC (genes):OXT OXT
CTD Gene:5020 OXT
dbSNP Gene:5020 OXT
ENSEMBL:ENSG00000101405 OXT
HGNC:8528 OXT
KEGG Gene (Homo sapiens):5020 OXT
Monarch:5020 OXT
NCBI Gene:5020 OXT
OMIM:167050 OXT
Reference Transcript
RefSeq:NM_000915.3 OXT
RefSeq:XM_011529238.1 OXT
Other Identifiers
0001400563
11737155_at
16910959
207576_x_at
32472_at
3874199
3874200
3874201
3874203
3874204
5020
8060604
A_14_P102709
A_24_P382579
GE57807
GO:0000003
GO:0001975
GO:0002027
GO:0002125
GO:0003013
GO:0003674
GO:0005179
GO:0005184
GO:0005185
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0006810
GO:0006950
GO:0007165
GO:0007186
GO:0007204
GO:0007267
GO:0007507
GO:0007565
GO:0007613
GO:0007625
GO:0008150
GO:0009744
GO:0010701
GO:0014070
GO:0014823
GO:0022607
GO:0030141
GO:0030431
GO:0031410
GO:0031855
GO:0032094
GO:0032308
GO:0032355
GO:0032526
GO:0032570
GO:0034330
GO:0034695
GO:0035176
GO:0035811
GO:0035815
GO:0042220
GO:0042538
GO:0042592
GO:0042711
GO:0042713
GO:0042755
GO:0042756
GO:0043195
GO:0043226
GO:0043434
GO:0044058
GO:0045472
GO:0045776
GO:0045777
GO:0045778
GO:0045925
GO:0048545
GO:0048856
GO:0050806
GO:0050877
GO:0051384
GO:0051591
GO:0051602
GO:0051930
GO:0051965
GO:0060179
GO:0060406
GO:0060450
GO:0060455
GO:0070474
GO:0120162
ILMN_1735124
M11186_at
PH_hs_0029103
TC20000033.hg
TC20001065.hg
g12707574_3p_at
Participant Of
input
Oxytocin receptor bind oxytocin
hasMember
Ligands of GPCRs that activate Gq/11 [extracellular region]
hasComponent
OXTR:OXT(20-28) [plasma membrane]
Inferred To
oxt [extracellular region] (Danio rerio)
oxt [extracellular region] (Xenopus tropicalis)
OXT [extracellular region] (Bos taurus)
OXT [extracellular region] (Canis familiaris)
OXT [extracellular region] (Gallus gallus)
OXT(20-28) [extracellular region] (Sus scrofa)
Oxt [extracellular region] (Mus musculus)
Oxt [extracellular region] (Rattus norvegicus)
Cross References
RefSeq
NP_000906.1
,
XP_011527540.1
OpenTargets
ENSG00000101405
GeneCards
P01178
HPA
ENSG00000101405-OXT
Ensembl
ENST00000217386
,
ENSP00000217386
,
ENSG00000101405
PRO
P01178
HMDB Protein
HMDBP01829
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHG0 DCDC2
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text