Reactome | Oxytocin receptor bind oxytocin

Oxytocin receptor bind oxytocin

Stable Identifier

R-HSA-388503

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Vasopressin-like receptors (Homo sapiens)
        
        Oxytocin receptor bind oxytocin (Homo sapiens)

General

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Oxytocin is a nonapetide closely related to vasopressin (Mohr E et al, 1985; Sausville E et al, 1985). It is best known for its roles in female reproduction: it is released in large amounts during labour facilitating birth and afterwards, breastfeeding. It also acts as a neurotransmitter in the brain. The actions of oxytocin via the oxytocin receptor (Kimura T et al, 1992) are mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Literature References

PubMed ID	Title	Journal	Year
1313946	Structure and expression of a human oxytocin receptor Mori, K, Kimura, T, Brownstein, MJ, Okayama, H, Tanizawa, O	Nature	1992
2991279	The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line Carney, D, Battey, J, Sausville, E	J Biol Chem	1985
4065330	Expression of the vasopressin and oxytocin genes in human hypothalami Richter, D, Ivell, R, Hillers, M, Haulica, ID, Mohr, E	FEBS Lett	1985