Cholecystokinin receptors bind cholecystokinin

Stable Identifier
R-HSA-388529
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cholecystokinin (CCK, previously called pancreozymin) (Takahashi Y et al,1985) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. CCK is synthesized by I-cells in the small intestine and secreted in the duodenum, causing the release of digestive enzymes and bile from the pancreas and gall-bladder respectively. It also acts as a hunger suppressant. CCK receptors bind CCK. In humans, there are two receptor types, A (Ulrich CD et al, 1993) and B (Pisegna JR et al, 1992). The A type are primarily distributed in the GI tract whereas the B type are primarily in the CNS. In the CNS, type B receptors modulate anxiety, analgesia, arousal, and neuroleptic activity.These receptors mediates the action of CCK by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Literature References
PubMed ID Title Journal Year
8503909 Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor

Buell, G, Ferber, I, Miller, LJ, Ulrich, CD, Holicky, E, Hadac, E

Biochem Biophys Res Commun 1993
1280419 Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization

de Weerth, A, Wank, SA, Pisegna, JR, Huppi, K

Biochem Biophys Res Commun 1992
3856870 Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine

Kato, K, Matsuki, S, Matsubara, K, Ohtsuka, E, Ikehara, M, Wakabayashi, T, Takahashi, Y, Hayashizaki, Y

Proc Natl Acad Sci U S A 1985
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!