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CCK [extracellular region]
Stable Identifier
R-HSA-388539
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
RecName: Full=Cholecystokinin; Short=CCK; Contains: RecName: Full=Cholecystokinin-58; Short=CCK58; Contains: RecName: Full=Cholecystokinin-58 desnonopeptide; AltName: Full=, CCKN_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCK [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCK [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCK [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCK [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCK [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
CCK [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Cholecystokinin receptors bind cholecystokinin (Homo sapiens)
CCK [extracellular region] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCK [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06307 CCK
Gene Names
CCK
Chain
signal peptide:1-20, chain:21-115, propeptide:21-44, peptide:46-103, peptide:46-94, peptide:65-103, peptide:71-103, peptide:79-103, peptide:86-103, peptide:92-103, peptide:96-103, peptide:97-103, peptide:99-103, propeptide:107-115
Reference Genes
BioGPS Gene:885 CCK
COSMIC (genes):CCK CCK
CTD Gene:885 CCK
dbSNP Gene:885 CCK
ENSEMBL:ENSG00000187094 CCK
ENSEMBL_homo_sapiens_GENE:ENSG00000187094.12 CCK
HGNC:1569 CCK
KEGG Gene (Homo sapiens):885 CCK
Monarch:885 CCK
NCBI Gene:885 CCK
OMIM:118440 CCK
Reference Transcript
RefSeq:NM_001174138.2 CCK
RefSeq:NM_000729.5 CCK
Other Identifiers
11724577_a_at
16952534
205827_PM_at
205827_at
2670726
2670727
2670731
2670733
2670734
2670735
2670736
2670737
2670738
2670739
37572_at
8086391
885
GE58231
GO:0001764
GO:0005179
GO:0005184
GO:0005515
GO:0005576
GO:0005615
GO:0007165
GO:0007409
GO:0007586
GO:0023052
GO:0030154
GO:0030424
GO:0042755
GO:0048018
GO:0048856
GO:0048870
GO:0051428
GO:0098772
HMNXSV003026901
ILMN_1712943
L00354_at
TC03001318.hg
g4755130_3p_at
Participates
as an input of
Cholecystokinin receptors bind cholecystokinin (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
Inferred To
Cck [extracellular region]
(Mus musculus)
Cck [extracellular region]
(Rattus norvegicus)
cck [extracellular region]
(Xenopus tropicalis)
CCK [extracellular region]
(Bos taurus)
CCK [extracellular region]
(Canis familiaris)
CCK [extracellular region]
(Gallus gallus)
CCK [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_000720.1
,
NP_001167609.1
OpenTargets
ENSG00000187094
GeneCards
P06307
HPA
ENSG00000187094-CCK
Ensembl
ENSP00000409124
,
ENSP00000379472
,
ENST00000334681
,
ENST00000434608
,
ENSP00000335657
,
ENSG00000187094
,
ENST00000396169
ZINC target
P06307
PRO
P06307
Pharos - Targets
P06307
PDB
8IA7
,
7MBX
,
7MBY
,
7EZK
,
7XOU
,
7EZM
,
7EZH
Interactors (58)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62701 RPS4X
2
RPS4X [nucleoplasm]
(R-HSA-6798713)
RPS4X [cytosol]
(R-HSA-72375)
0.556
3
UniProt:Q96BD6 SPSB1
1
SPSB1 [cytosol]
(R-HSA-976024)
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:C1IDX9 C1IDX9
0.556
3
IntAct:EBI-25836264 CCSB
0.556
3
UniProt:Q8NI22 MCFD2
3
MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689836)
MCFD2 [ER to Golgi transport vesicle membrane]
(R-HSA-1017216)
MCFD2 [endoplasmic reticulum membrane]
(R-HSA-5689470)
0.556
3
UniProt:Q16609 LPAL2
0.556
3
UniProt:Q5W111-2 SPRYD7
0.556
3
UniProt:Q9H2C1 LHX5
0.556
3
UniProt:O00257-3 CBX4
0.556
3
UniProt:Q9P1Q0-4 VPS54
0.556
3
UniProt:Q494V2-2 CFAP100
0.556
3
UniProt:Q6NXT2 H3C
0.556
3
UniProt:Q7L8J4 3BP5L
0.556
3
UniProt:Q9NX94 WBP1L
0.556
3
UniProt:Q07869 PPARA
2
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
PPARA [nucleoplasm]
(R-HSA-400186)
0.556
3
UniProt:P62253 UBE2G1
2
Ub-C90-UBE2G1 [cytosol]
(R-HSA-8864149)
UBE2G1 [cytosol]
(R-HSA-947627)
0.556
3
UniProt:Q9Y3D0 CIAO2B
1
FAM96B [cytosol]
(R-HSA-2161124)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q8N1A0 KT222
0.556
3
UniProt:Q66K80 RUAS1
0.556
3
UniProt:Q6DHV7-2 Q6DHV72
0.556
3
UniProt:Q15382 RHEB
2
RHEB [endosome membrane]
(R-HSA-5656350)
RHEB [lysosomal membrane]
(R-HSA-165190)
0.556
3
IntAct:EBI-25835796 CCSB
0.556
3
UniProt:O95278-6 O952786
0.556
3
UniProt:Q9NU02 ANKE1
0.556
3
UniProt:Q9C004 SPY4
0.556
3
UniProt:P02775 PPBP
5
PPBP(55-128) [extracellular region]
(R-HSA-114638)
PPBP(55-128) [platelet alpha granule lumen]
(R-HSA-114637)
PPBP(35-128) [platelet alpha granule lumen]
(R-HSA-114572)
PPBP(35-128) [tertiary granule lumen]
(R-HSA-6800185)
PPBP(35-128) [extracellular region]
(R-HSA-114573)
0.556
3
UniProt:Q6NXG1-3 Q6NXG13
0.556
3
UniProt:Q53FD0-2 ZC2HC1C
0.556
3
UniProt:Q7Z3B4 NUP54
2
NUP54 [cytosol]
(R-HSA-9634221)
NUP54 [nuclear envelope]
(R-HSA-157724)
0.556
3
UniProt:Q6ZMI0-5 PPP1R21
0.556
3
UniProt:Q9UK76 JUPI1
0.556
3
UniProt:Q96HR9-2 REEP6
0.556
3
UniProt:Q66PJ3-4 ARL6IP4
0.556
3
UniProt:Q9NRZ9-6 HELLS
0.556
3
UniProt:Q6XD76 ASCL4
0.556
3
UniProt:Q8NFH3 NUP43
2
NUP43 [nuclear envelope]
(R-HSA-157739)
NUP43 [cytosol]
(R-HSA-376243)
0.556
3
UniProt:P47804-3 P478043
0.556
3
UniProt:Q6DKI2 LEG9C
0.556
3
IntAct:EBI-25836274 CCSB
0.556
3
UniProt:O75409 HYPM
0.556
3
UniProt:Q8IWT0-2 ZBTB8OS
0.556
3
UniProt:Q9UJ70-2 NAGK
0.556
3
UniProt:Q92797-2 Q927972
0.556
3
UniProt:Q8IYM2 SLN12
0.556
3
UniProt:Q9NSI6-4 BRWD1
0.556
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.556
3
UniProt:Q06547-3 GABPB1
1
NRF2 gamma-1 subunit [nucleoplasm]
(R-HSA-1592216)
0.556
3
UniProt:Q99966 CITED1
1
CITED1 [nucleoplasm]
(R-HSA-8864301)
0.556
3
UniProt:P53701 HCCS
1
HCCS [mitochondrial inner membrane]
(R-HSA-9866218)
0.556
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.556
3
UniProt:P29074 PTPN4
2
PTPN4 [nucleoplasm]
(R-HSA-9008925)
PTPN4 [cytosol]
(R-HSA-8877173)
0.556
3
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.556
3
UniProt:Q8WUX9 CHMP7
2
CHMP7 [cytosol]
(R-HSA-917703)
CHMP7 [endosome membrane]
(R-HSA-9631168)
0.556
3
UniProt:P25208 NFYB
1
NFYB [nucleoplasm]
(R-HSA-381067)
0.556
3
UniProt:P23942 PRPH2
0.556
3
UniProt:Q96JL9-2 Q96JL92
0.556
3
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