Reactome | POMC(138-176) binds MC2R

POMC(138-176) binds MC2R

Stable Identifier

R-HSA-388605

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

ACTH binds MC2R

ReviewStatus

5/5

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MC2R (aka ACTH receptor) selectively binds POMC(138-176) (ACTH, corticotropin) (Gantz et al. 1993, Lee et al. 1961, Mountjoy et al. 1992). ACTH regulates adrenal cortical function via the G protein alpha-s subunit.

Literature References

PubMed ID	Title	Journal	Year
1325670	The cloning of a family of genes that encode the melanocortin receptors Robbins, LS, Cone, RD, Mortrud, MT, Mountjoy, KG	Science	1992
8463333	Molecular cloning of a novel melanocortin receptor Gantz, I, Yamada, T, Shimoto, Y, Miwa, H, Tashiro, T, Konda, Y, Munzert, G, Watson, SJ, DelValle, J	J Biol Chem	1993
14463577	On the structure of human corticotropin (adrenocorticotropic hormone) Lerner, AB, Buettner-Janusch, V, Lee, TH	J Biol Chem	1961