POMC(138-176) binds MC2R

Stable Identifier
R-HSA-388605
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
ACTH binds MC2R
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MC2R (aka ACTH receptor) selectively binds POMC(138-176) (ACTH, corticotropin) (Gantz et al. 1993, Lee et al. 1961, Mountjoy et al. 1992). ACTH regulates adrenal cortical function via the G protein alpha-s subunit.

Literature References
PubMed ID Title Journal Year
8463333 Molecular cloning of a novel melanocortin receptor

Gantz, I, Konda, Y, Tashiro, T, Shimoto, Y, Miwa, H, Munzert, G, Watson, SJ, DelValle, J, Yamada, T

J Biol Chem 1993
1325670 The cloning of a family of genes that encode the melanocortin receptors

Mountjoy, KG, Robbins, LS, Mortrud, MT, Cone, RD

Science 1992
14463577 On the structure of human corticotropin (adrenocorticotropic hormone)

Lee, TH, Lerner, AB, Buettner-Janusch, V

J Biol Chem 1961
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