Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
MC4R [plasma membrane]
Stable Identifier
R-HSA-388606
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Melanocortin receptor 4; AltName: Full=MC4-R;
GN Name=MC4R;
OS Homo sapiens, MC4R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC4R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC4R [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC4R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC4R [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC4R [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC4R [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Melanocortin receptors bind melanocortins (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC4R [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC4R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32245 MC4R
Gene Names
MC4R
Chain
chain:1-332
Reference Genes
BioGPS Gene:4160 MC4R
COSMIC (genes):MC4R MC4R
CTD Gene:4160 MC4R
dbSNP Gene:4160 MC4R
ENSEMBL:ENSG00000166603 MC4R
ENSEMBL:ENSG00000166603.5 MC4R
HGNC:6932 MC4R
KEGG Gene (Homo sapiens):4160 MC4R
Monarch:4160 MC4R
NCBI Gene:4160 MC4R
OMIM:155541 MC4R
UCSC:P32245 MC4R
Reference Transcript
RefSeq:NM_005912.2 MC4R
Other Identifiers
11735468_at
16855617
221467_PM_at
221467_at
3810750
3810751
4160
8023593
A_23_P50121
GE58811
GO:0002024
GO:0004930
GO:0004977
GO:0004980
GO:0005515
GO:0005886
GO:0006091
GO:0006112
GO:0007165
GO:0007186
GO:0007188
GO:0007189
GO:0007631
GO:0016020
GO:0017046
GO:0019222
GO:0023052
GO:0030073
GO:0031625
GO:0032868
GO:0042562
GO:0042923
GO:0045780
GO:0060089
GO:0060259
GO:1903998
GO:1990680
GO:2000252
GO:2000821
HMNXSV003001286
ILMN_1722445
PH_hs_0013133
S77415_at
TC18000550.hg
g5174532_3p_at
Participates
as a member of
Melanocortin receptors [plasma membrane] (Homo sapiens)
Inferred To
Mc4r [plasma membrane]
(Mus musculus)
Mc4r [plasma membrane]
(Rattus norvegicus)
MC4R [plasma membrane]
(Bos taurus)
MC4R [plasma membrane]
(Canis familiaris)
MC4R [plasma membrane]
(Gallus gallus)
MC4R [plasma membrane]
(Sus scrofa)
MC4R [plasma membrane]
(Xenopus tropicalis)
mc4r [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_005903.2
ZINC - World Drugs
MC4R_HUMAN
Guide to Pharmacology - Targets
285
OpenTargets
ENSG00000166603
ZINC - FDA approved
MC4R_HUMAN
ZINC - Substances
MC4R_HUMAN
ZINC target
P32245
PRO
P32245
PDB
7F58
,
7F53
,
7PIV
,
7AUE
,
7F54
,
6W25
,
7F55
,
7PIU
ZINC - Investigational
MC4R_HUMAN
GeneCards
P32245
HPA
ENSG00000166603-MC4R
Ensembl
ENST00000299766
,
ENSP00000299766
,
ENSG00000166603
Pharos - Targets
P32245
Orphanet
17731
ZINC - Predictions - Purchasable
MC4R_HUMAN
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text