Reactome | MC4R [plasma membrane]

MC4R [plasma membrane]

Stable Identifier

R-HSA-388606

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Melanocortin receptor 4; AltName: Full=MC4-R;
GN Name=MC4R;
OS Homo sapiens, MC4R_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
    - p-S133-CREB1 binds MITF promoter (Homo sapiens)
      - MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Melanocortin receptors bind melanocortins (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC4R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P32245 MC4R

Gene Names

MC4R

Chain

chain:1-332

Reference Genes

BioGPS Gene:4160 MC4R

COSMIC (genes):MC4R MC4R

CTD Gene:4160 MC4R

dbSNP Gene:4160 MC4R

ENSEMBL:ENSG00000166603 MC4R

ENSEMBL_homo_sapiens_GENE:ENSG00000166603.5 MC4R

HGNC:6932 MC4R

KEGG Gene (Homo sapiens):4160 MC4R

Monarch:4160 MC4R

NCBI Gene:4160 MC4R

OMIM:155541 MC4R

UCSC:P32245 MC4R

Reference Transcript

RefSeq:NM_005912.2 MC4R

Other Identifiers

11735468_at

16855617

221467_PM_at

221467_at

3810750

3810751

4160

8023593

A_23_P50121

GE58811

GO:0002024

GO:0004930

GO:0004977

GO:0004980

GO:0005515

GO:0005737

GO:0005886

GO:0006091

GO:0006112

GO:0007165

GO:0007186

GO:0007188

GO:0007189

GO:0007631

GO:0016020

GO:0017046

GO:0019222

GO:0023052

GO:0030073

GO:0031625

GO:0032868

GO:0042562

GO:0042923

GO:0045780

GO:0060089

GO:0060259

GO:1903998

GO:1990680

GO:2000252

GO:2000821

HMNXSV003001286

ILMN_1722445

PH_hs_0013133

S77415_at

TC18000550.hg

g5174532_3p_at

Participates

as a member of

Melanocortin receptors [plasma membrane] (Homo sapiens)

Inferred To

Mc4r [plasma membrane] (Mus musculus)

Mc4r [plasma membrane] (Rattus norvegicus)

MC4R [plasma membrane] (Bos taurus)

MC4R [plasma membrane] (Canis familiaris)

MC4R [plasma membrane] (Gallus gallus)

MC4R [plasma membrane] (Sus scrofa)

mc4r [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_005903.2

ZINC - World Drugs

MC4R_HUMAN

Guide to Pharmacology - Targets

285

OpenTargets

ENSG00000166603

ZINC - FDA approved

MC4R_HUMAN

ZINC - Substances

MC4R_HUMAN

ZINC target

P32245

PRO

P32245

PDB

7PIV, 7F58, 7F53, 7F55, 7PIU, 6W25, 7F54, 7AUE

ZINC - Investigational

MC4R_HUMAN

HPA

ENSG00000166603-MC4R

GeneCards

P32245

Ensembl

ENST00000299766, ENSG00000166603, ENSP00000299766

Pharos - Targets

P32245

ZINC - Predictions - Purchasable

MC4R_HUMAN

Orphanet

17731