PD-1 binds B7DC and B7H1

Stable Identifier
R-HSA-388828
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The Programmed cell death protein 1 (PD-1) is functionally similar to CTLA4 and exerts an inhibitory signal on T cell activation. PD-1 binds the ligands B7H1 and B7DC but with different affinities. Interaction of PD-1/B7DC exhibited a 2-6-fold higher affinity and had different association/dissociation kinetics compared with the interaction of PD-1/B7H1.

Literature References
PubMed ID Title Journal Year
12893276 Differential binding properties of B7-H1 and B7-DC to programmed death-1

Youngnak, P, Kozono, Y, Kozono, H, Iwai, H, Otsuki, N, Jin, H, Omura, K, Yagita, H, Pardoll, DM, Chen, L, Azuma, M

Biochem Biophys Res Commun 2003
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