PI3K binds CD28

Stable Identifier
R-HSA-388832
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PI3K inducibly associates with CD28: the SH2 domains of the PI3K p85 adaptor subunit interact with a cytoplasmic YMNM consensus motif at residues 173-176 of CD28.

Literature References
PubMed ID Title Journal Year
12670391 The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3

Kane, LP, Weiss, A

Immunol Rev 2003
8621607 Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association

Pag├Ęs, F, Ragueneau, M, Klasen, S, Battifora, M, Couez, D, Sweet, R, Truneh, A, Ward, SG, Olive, D

J Biol Chem 1996
Participants
Participant Of
Orthologous Events
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Created