Phosphorylation of CTLA-4

Stable Identifier
R-HSA-388833
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Upon TCR-CTLA-4 complex formation, CTLA4 is tyrosine phosphorylated. Src family tyrosine kinases Fyn, Lyn, and Lck associate with CTLA-4 and phosphorylate both Y-201 and Y-218 that are mainly responsible for interaction with Fyn through its SH2 domain (Marengere et al. 1996). Once tyrosine 165 is phosphorylated, PP2A is activated and disassociates from CTLA4; this correlates with T cell inactivation.
Literature References
PubMed ID Title Journal Year
9712716 Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152)

Nakaseko, C, Yamamoto, T, Miyatake, S, Umemori, H, Saito, T

Biochem Biophys Res Commun 1998
11994459 Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A

Darlington, PJ, Vijayakrishnan, L, Madrenas, J, Baroja, ML, Collins, M, Ling, V, Carreno, BM, Chau, TA, Bettelli, E, Kuchroo, VK

J Immunol 2002
8638161 Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

Waterhouse, P, Mittrücker, HW, Marengère, LE, Feng, GS, Duncan, GS, Mak, TW

Science 1996
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Src family tyrosine kinases (SFKs) [cytosol]

Orthologous Events
Authored
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