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NPY2R [plasma membrane]
Stable Identifier
R-HSA-388905
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Neuropeptide Y receptor type 2; Short=NPY2-R; AltName: Full=NPY-Y2 receptor; Short=Y2 receptor;
GN Name=NPY2R;
OS Homo sapiens, NPY2R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
NPY2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
NPY2R [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
NPY2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
NPY2R [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
NPY2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
NPY2R [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
NPY2R [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
NPY2R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49146 NPY2R
Gene Names
NPY2R
Chain
chain:1-381
Reference Genes
BioGPS Gene:4887 NPY2R
COSMIC (genes):NPY2R NPY2R
CTD Gene:4887 NPY2R
dbSNP Gene:4887 NPY2R
ENSEMBL:ENSG00000185149 NPY2R
HGNC:7957 NPY2R
KEGG:hsa:4887 NPY2R
Monarch:4887 NPY2R
NCBI Gene:4887 NPY2R
OMIM:162642 NPY2R
UCSC:P49146 NPY2R
Reference Transcript
RefSeq:XM_005263033.4 NPY2R
RefSeq:XM_005263034.4 NPY2R
RefSeq:NM_000910.3 NPY2R
Other Identifiers
11735784_at
11735785_a_at
16971691
210729_PM_at
210729_at
210730_PM_s_at
210730_s_at
2748727
2748728
2748729
2748732
2748733
2748734
2748736
33525_at
4887
8097938
A_23_P58169
A_33_P3396244
GE80127
GO:0001601
GO:0003151
GO:0003214
GO:0004930
GO:0004983
GO:0005246
GO:0005515
GO:0005886
GO:0005929
GO:0007186
GO:0007193
GO:0007218
GO:0007626
GO:0016020
GO:0038023
GO:0043226
GO:0060089
GO:0097730
GO:0098772
HMNXSV003019454
ILMN_1660360
PH_hs_0027631
TC04000782.hg
g1000750_3p_at
g1063633_3p_a_at
g4505446_3p_s_at
g4505446_3p_x_at
Participates
as a member of
Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
Inferred To
npy2r [plasma membrane]
(Xenopus tropicalis)
Npy2r [plasma membrane]
(Mus musculus)
NPY2R [plasma membrane]
(Bos taurus)
NPY2R [plasma membrane]
(Canis familiaris)
NPY2R [plasma membrane]
(Gallus gallus)
NPY2R [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000901.1
,
XP_005263090.1
,
XP_005263091.1
Guide to Pharmacology - Targets
306
ENSEMBL
ENST00000506608
,
ENST00000329476
,
ENSP00000332591
,
ENSP00000426366
OpenTargets
ENSG00000185149
ZINC - Substances
NPY2R_HUMAN
ZINC target
P49146
PRO
P49146
GlyGen
P49146
PDB
7X9B
,
7YOO
,
7YON
ZINC - Investigational
NPY2R_HUMAN
HPA
ENSG00000185149-NPY2R
Pharos - Targets
P49146
ZINC - Predictions - Purchasable
NPY2R_HUMAN
HMDB Protein
HMDBP13636
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13315 ATM
5
ATM [cytosol]
(R-HSA-9665171)
ATM [peroxisomal matrix]
(R-HSA-9665169)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [nucleoplasm]
(R-HSA-69484)
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
0.527
2
UniProt:O43808 SLC25A17
2
SLC25A17 [cytosol]
(R-HSA-9603781)
SLC25A17 [peroxisomal membrane]
(R-HSA-389642)
0.527
2
UniProt:Q7L8L6 FASTKD5
1
FASTKD5 [mitochondrial matrix]
(R-HSA-9837206)
0.527
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.527
2
UniProt:Q6JQN1 ACAD10
1
ACAD10 [mitochondrial matrix]
(R-HSA-5695955)
0.527
2
UniProt:Q8TAG9 EXOC6
2
EXOC6 [plasma membrane]
(R-HSA-265041)
EXOC6 [cytosol]
(R-HSA-5623384)
0.527
2
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.527
2
UniProt:O15360 FANCA
2
FANCA [cytosol]
(R-HSA-420796)
FANCA [nucleoplasm]
(R-HSA-419541)
0.527
2
UniProt:Q9UK39 NOCT
1
CCRN4L [nucleoplasm]
(R-HSA-508391)
0.527
2
UniProt:Q5T160 RARS2
1
RARS2 [mitochondrial matrix]
(R-HSA-379589)
0.527
2
UniProt:Q92538 GBF1
2
GBF1 [cytosol]
(R-HSA-6807751)
GBF1 [Golgi membrane]
(R-HSA-199994)
0.527
2
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