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NTS(151-163) [extracellular region]
Stable Identifier
R-HSA-388915
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neurotensin, RecName: Full=Neurotensin/neuromedin N; Contains: RecName: Full=Large neuromedin N; AltName: Full=NmN-125; Contains: RecName: Full=Neuromedin N; Short=NmN; Short=NN; Contains: RecName: Full=Neurotensin; Short=NT; Contains: RecName: Full=Tail peptide; Flags: Precursor; GN Name=NTS; OS Homo sapiens, NEUT_HUMAN, NTS
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Neurolysin degrades neurotensin (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
Neurotensin receptors can bind neurotensins (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTS(151-163) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30990 NTS
Gene Names
NTS
Chain
signal peptide:1-23, chain:24-148, peptide:144-148, peptide:151-163, peptide:166-170
Reference Genes
BioGPS Gene:4922 NTS
COSMIC (genes):NTS NTS
CTD Gene:4922 NTS
dbSNP Gene:4922 NTS
ENSEMBL:ENSG00000133636 NTS
HGNC:8038 NTS
KEGG Gene (Homo sapiens):4922 NTS
Monarch:4922 NTS
NCBI Gene:4922 NTS
OMIM:162650 NTS
Reference Transcript
RefSeq:NM_006183.4 NTS
Other Identifiers
0001500041
11719684_a_at
11719685_at
16754895
206291_at
33998_at
3424899
3424900
3424901
3424902
3424903
3424904
3424905
3424906
4922
78358_at
7957458
A_14_P100451
A_23_P36882
GE79384
GO:0003674
GO:0005184
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005737
GO:0007165
GO:0007186
GO:0007218
GO:0008150
GO:0030133
GO:0031410
GO:0043226
GO:0043679
GO:0048018
GO:0071855
ILMN_1764690
ILMN_2189366
PH_hs_0004650
PH_hs_0035472
TC12000687.hg
U91618_at
g6006028_3p_s_at
Participant Of
input
Neurolysin degrades neurotensin
Neurotensin receptors can bind neurotensins
hasMember
Ligands of GPCRs that activate Gq/11 [extracellular region]
hasComponent
NTSR1,NTSR2:NTS(151-163) [plasma membrane]
Other forms of this molecule
NTS(151-160) [extracellular region]
NTS(161-163) [extracellular region]
Inferred To
NTS [extracellular region] (Bos taurus)
NTS [extracellular region] (Canis familiaris)
NTS [extracellular region] (Sus scrofa)
nts [extracellular region] (Danio rerio)
Nts [extracellular region] (Mus musculus)
Nts [extracellular region] (Rattus norvegicus)
Cross References
RefSeq
NP_006174.1
OpenTargets
ENSG00000133636
HPA
ENSG00000133636-NTS
GeneCards
P30990
Ensembl
ENST00000256010
,
ENSG00000133636
,
ENSP00000256010
PRO
P30990
PDB
3F6K
,
4PO7
,
2OYW
,
2LNG
,
2LNE
,
5LUZ
,
2LYW
,
2OYV
,
6UP7
,
2LNF
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99523 SORT1
2
SORT1 [Golgi membrane]
(R-HSA-434332)
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
0.609
2
UniProt:P30989 NTSR1
1
NTSR1 [plasma membrane]
(R-HSA-388916)
0.558
2
UniProt:Q9GZY8-5 MFF
0.556
3
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