Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
KISS1(68-121) [extracellular region]
Stable Identifier
R-HSA-389043
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Metastin
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
The Kiss receptor GPR54 binds kisspeptin (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
KISS1R:KISS1(68-121) [plasma membrane] (Homo sapiens)
KISS1(68-121) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15726 KISS1
Gene Names
KISS1, PP5098
Chain
signal peptide:1-19, chain:20-138, peptide:68-121, peptide:108-121, peptide:109-121, peptide:112-121
Reference Genes
BioGPS Gene:3814 KISS1
COSMIC (genes):KISS1 KISS1
CTD Gene:3814 KISS1
dbSNP Gene:3814 KISS1
ENSEMBL:ENSG00000170498 KISS1
HGNC:6341 KISS1
KEGG Gene (Homo sapiens):3814 KISS1
Monarch:3814 KISS1
NCBI Gene:3814 KISS1
OMIM:603286 KISS1
UCSC:Q15726 KISS1
Reference Transcript
RefSeq:NM_002256.3 KISS1
Other Identifiers
0005670541
11715454_at
11715455_x_at
1645_at
16698298
205563_at
2451919
2451920
2451921
2451922
2451923
2451925
2451926
2451928
3814
7923621
A_23_P124892
GE59168
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0007010
GO:0007165
GO:0007186
GO:0007204
GO:0008150
GO:0031773
GO:0042592
GO:0043005
ILMN_1669404
PH_hs_0005191
TC01003727.hg
U43527_at
g4504872_3p_at
Participant Of
input
The Kiss receptor GPR54 binds kisspeptin
hasMember
Ligands of GPCRs that activate Gq/11 [extracellular region]
hasComponent
KISS1R:KISS1(68-121) [plasma membrane]
Inferred To
kiss1 [extracellular region] (Danio rerio)
Ghost homologue of KISS1(68-121) [extracellular region] (Xenopus tropicalis)
Kiss1 [extracellular region] (Mus musculus)
Kiss1 [extracellular region] (Rattus norvegicus)
KISS1 [extracellular region] (Bos taurus)
KISS1 [extracellular region] (Sus scrofa)
Cross References
RefSeq
NP_002247.3
OpenTargets
ENSG00000170498
GeneCards
Q15726
HPA
ENSG00000170498-KISS1
Ensembl
ENSP00000356162
,
ENST00000367194
,
ENSG00000170498
PRO
Q15726
Orphanet
20822
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text