Autophosphorylation of PDGF alpha receptors

Stable Identifier
R-HSA-389083
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Receptor dimerisation is key event in PDGF receptor activation. The intracellular parts of the receptors are juxtaposed which allows trans-phosphorylation between the two receptors in the complex.
The autophosphorylation site Y857 located inside the kinase domain of beta-receptor is important for activation of the kinase. This tyrosine is conserved in the alpha-receptor (Y849 ) and in almost all other tyrosine kinase receptors. The other known autophosphorylation sites are localized outside the kinase domains of the alpha- and beta- receptors ; 11 out of 15 tyrosine residues in the intracellular, non-catalytic part of the beta-receptor are autophosphorylation sites

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of PDGF alpha receptor: PDGF dimers [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created