Reactome | RBL1 [nucleoplasm]

RBL1 [nucleoplasm]

Stable Identifier

R-HSA-389104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p107, p107 (RBL1)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P28749 RBL1

Gene Names

RBL1

Chain

chain:1-1068

Reference Genes

BioGPS Gene:5933 RBL1

COSMIC (genes):RBL1 RBL1

CTD Gene:5933 RBL1

dbSNP Gene:5933 RBL1

ENSEMBL:ENSG00000080839 RBL1

HGNC:9893 RBL1

KEGG:hsa:5933 RBL1

Monarch:5933 RBL1

NCBI Gene:5933 RBL1

OMIM:116957 RBL1

UCSC:P28749 RBL1

Reference Transcript

Other Identifiers

11738630_a_at

11740382_at

11740383_at

1555003_PM_at

1555003_at

1555004_PM_a_at

1555004_a_at

1559307_PM_s_at

1559307_s_at

16919044

1907_at

205296_PM_at

205296_at

3904748

3904749

3904750

3904752

3904753

3904754

3904756

3904760

3904763

3904766

3904768

3904769

3904770

3904771

3904772

3904774

3904775

3904776

3904777

3904778

3904779

3904780

3904782

3904783

3904784

3904785

3904786

3904787

3904789

3904792

3904793

3904794

5933

77729_r_at

8066136

A_23_P28733

A_24_P276102

GE81207

GO:0000122

GO:0000785

GO:0000977

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0006325

GO:0006355

GO:0006357

GO:0010629

GO:0030154

GO:0043226

GO:0043550

GO:0051726

GO:1990841

GO:2000134

GO:2000773

HMNXSV003012951

HMNXSV003042054

Hs.87.0.S2_3p_x_at

Hs2.406930.1.S1_3p_s_at

Hs2.87.2.S1_3p_at

Hs2.87.2.S1_3p_s_at

ILMN_1753013

ILMN_1782745

L14812_at

PH_hs_0000013

TC20000822.hg

Participates

as an output of

as a component of

as an input of

p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)

as a candidate of

RBL1,RBL2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-T369,S640,S964,S975-RBL1 [nucleoplasm]

Inferred To

RBL1 [nucleoplasm] (Bos taurus)

RBL1 [nucleoplasm] (Canis familiaris)

RBL1 [nucleoplasm] (Gallus gallus)

RBL1 [nucleoplasm] (Sus scrofa)

lin-35 [nucleoplasm] (Caenorhabditis elegans)

rbl1 [nucleoplasm] (Danio rerio)

rbl1 [nucleoplasm] (Xenopus tropicalis)

Rbl1 [nucleoplasm] (Mus musculus)

Rbl1 [nucleoplasm] (Rattus norvegicus)

Homologues of RBL1 [nucleoplasm] (Drosophila melanogaster)

Rbf [nucleoplasm] (Drosophila melanogaster)

rblA [nucleoplasm] (Dictyostelium discoideum)

Rbf2 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_002886.2, NP_899662.1

OpenTargets

ENSG00000080839

ENSEMBL

ENST00000373664, ENSG00000080839, ENSP00000343646, ENSP00000362768, ENST00000344359

HPA

ENSG00000080839-RBL1

GeneCards

RBL1

PRO

P28749

Pharos - Targets

P28749

GlyGen

P28749

PDB

7SMF, 4YOO, 4YOS, 7SMC, 4YOZ, 7SME, 7SMD, 5TUV, 1H28

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.837	9
UniProt:P03129 VE7			0.825	5
UniProt:P06788 VE7			0.737	4
UniProt:Q9Y463 DYR1B			0.67	4
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.67	4
UniProt:P03255 E1A			0.591	3
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.564	2
UniProt:P06430 VE7			0.547	2
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.544	2
UniProt:Q6ZUJ4 CC062			0.527	2
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.527	2
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.527	4
UniProt:P24610	1	Pax3 [nucleoplasm] (R-MMU-5603237)	0.524	3
UniProt:Q923E4 Sirt1	2	Sirt1 [nucleoplasm] (R-MMU-5211238) SIRT1 [nucleoplasm] (R-MMU-427531)	0.524	2
UniProt:Q13574-2 DGKZ			0.524	2
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.508	2
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.499	2
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.499	3

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