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CBX2 [nucleoplasm]
Stable Identifier
R-HSA-389110
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14781 CBX2
Gene Names
CBX2
Chain
chain:1-532
Reference Genes
BioGPS Gene:84733 CBX2
COSMIC (genes):CBX2 CBX2
CTD Gene:84733 CBX2
dbSNP Gene:84733 CBX2
ENSEMBL:ENSG00000173894 CBX2
ENSEMBL_homo_sapiens_GENE:ENSG00000173894.11 CBX2
HGNC:1552 CBX2
KEGG Gene (Homo sapiens):84733 CBX2
Monarch:84733 CBX2
NCBI Gene:84733 CBX2
OMIM:602770 CBX2
UCSC:Q14781 CBX2
Reference Transcript
RefSeq:NM_005189.2 CBX2
RefSeq:NM_032647.3 CBX2
Other Identifiers
11722710_at
11738166_at
11738167_x_at
16838464
215989_PM_at
215989_at
224138_PM_at
224138_at
226473_PM_at
226473_at
31520_at
3736986
3736987
3736988
3736989
3736993
3736994
3736995
3736997
3736998
3736999
3737000
3737002
3737004
3737005
56190_at
8010320
84733
A_23_P353567
A_33_P3423949
A_33_P3423954
GE56825
GO:0000122
GO:0000791
GO:0000792
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006351
GO:0006355
GO:0007548
GO:0022414
GO:0030154
GO:0031519
GO:0035064
GO:0035102
GO:0042393
GO:0043226
GO:0045137
GO:0045892
GO:0048856
HMNXSV003010527
HMNXSV003025080
Hs.103305.0.S1_3p_at
Hs.307356.0.S1_3p_at
ILMN_1686237
ILMN_1709645
ILMN_1770678
PH_hs_0024418
PH_hs_0037318
TC17000911.hg
TC17002398.hg
g13279025_3p_at
Participates
as a component of
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
as a member of
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
Inferred To
CBX2 [nucleoplasm]
(Bos taurus)
CBX2 [nucleoplasm]
(Canis familiaris)
CBX2 [nucleoplasm]
(Gallus gallus)
CBX2 [nucleoplasm]
(Sus scrofa)
Cbx2 [nucleoplasm]
(Mus musculus)
Cbx2 [nucleoplasm]
(Rattus norvegicus)
cbx2 [nucleoplasm]
(Xenopus tropicalis)
pc1 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_116036.1
,
NP_005180.1
OpenTargets
ENSG00000173894
GeneCards
Q14781
HPA
ENSG00000173894-CBX2
Ensembl
ENSP00000269399
,
ENST00000310942
,
ENSP00000308750
,
ENSG00000173894
,
ENST00000269399
PRO
Q14781
Pharos - Targets
Q14781
Orphanet
19343
PDB
2D9U
,
3H91
,
5EPK
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.725
4
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