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PHC1 [nucleoplasm]
Stable Identifier
R-HSA-389111
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Polyhomeotic-like protein 1, HPH1, EDR1, Early development regulatory protein 1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
E2F6 binds the PRC1 complex (Homo sapiens)
E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
PHC1,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
PHC1,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78364 PHC1
Gene Names
PHC1, EDR1, PH1
Chain
chain:1-1004
Reference Genes
BioGPS Gene:1911 PHC1
COSMIC (genes):PHC1 PHC1
CTD Gene:1911 PHC1
dbSNP Gene:1911 PHC1
ENSEMBL:ENSG00000111752 PHC1
ENSEMBL_homo_sapiens_GENE:ENSG00000111752.11 PHC1
HGNC:3182 PHC1
KEGG Gene (Homo sapiens):1911 PHC1
Monarch:1911 PHC1
NCBI Gene:1911 PHC1
OMIM:602978 PHC1
UCSC:P78364 PHC1
Reference Transcript
RefSeq:NM_004426.2 PHC1
Other Identifiers
11719511_s_at
11719512_s_at
11746622_a_at
11752468_s_at
16748061
16765683
1911
218338_PM_at
218338_at
225958_PM_at
225958_at
3403982
3403985
3403986
3403988
3403990
3403991
3403992
3403993
3403995
3403996
3403997
3403998
3403999
3404000
3404001
3404003
3404005
3404007
3404008
3404009
3404010
3404011
3404013
3404014
3404015
3404016
3404017
3404018
3404019
3404020
3404021
3404022
3404023
3404025
3457044
3457045
3457046
3457047
3457048
3457049
3457050
3457051
3457052
3457053
3457054
3457055
3457056
3457057
3457058
3457059
3457060
3457061
3457063
3457064
60396_at
7953812
7963869
A_14_P139045
A_23_P204246
A_23_P323094
A_33_P3378644
GE81395
GE85669
GO:0001739
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008270
GO:0016604
GO:0031519
GO:0032991
GO:0035102
GO:0042393
GO:0043226
GO:0045892
GO:0046872
GO:0071300
GO:1990830
HMNXSV003037556
Hs.75709.1.A1_3p_at
ILMN_1737950
ILMN_1796710
PH_hs_0027366
TC12000137.hg
TC12002904.hg
g11038623_3p_s_at
Participates
as a component of
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
as a member of
PHC1,PHC3 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
Inferred To
PHC1 [nucleoplasm]
(Bos taurus)
PHC1 [nucleoplasm]
(Canis familiaris)
PHC1 [nucleoplasm]
(Gallus gallus)
PHC1 [nucleoplasm]
(Mus musculus)
PHC1 [nucleoplasm]
(Sus scrofa)
ph-d [nucleoplasm]
(Drosophila melanogaster)
phc1 [nucleoplasm]
(Xenopus tropicalis)
Phc1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_004417.2
OpenTargets
ENSG00000111752
GeneCards
P78364
HPA
ENSG00000111752-PHC1
Ensembl
ENSP00000437659
,
ENST00000544916
,
ENSP00000440674
,
ENST00000543824
,
ENSG00000111752
PRO
P78364
Pharos - Targets
P78364
Orphanet
21867
PDB
2L8E
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.884
11
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