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PHC2 [nucleoplasm]
Stable Identifier
R-HSA-389112
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Polyhomeotic-like protein 2, HPH2, EDR2, Early development regulatory protein 2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IXK0 PHC2
Gene Names
PHC2, EDR2, PH2
Chain
chain:1-858
Reference Genes
COSMIC (genes):PHC2 PHC2
dbSNP Gene:1912 PHC2
ENSEMBL:ENSG00000134686 PHC2
Participates
as a component of
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
as a member of
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
Inferred To
PHC2 [nucleoplasm]
(Bos taurus)
PHC2 [nucleoplasm]
(Canis familiaris)
PHC2 [nucleoplasm]
(Danio rerio)
PHC2 [nucleoplasm]
(Drosophila melanogaster)
PHC2 [nucleoplasm]
(Mus musculus)
PHC2 [nucleoplasm]
(Sus scrofa)
phc2 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of PHC2 [nucleoplasm]
(Gallus gallus)
ph-d [nucleoplasm]
(Drosophila melanogaster)
Phc2 [nucleoplasm]
(Rattus norvegicus)
Homologues of PHC2 [nucleoplasm]
(Drosophila melanogaster)
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.858
10
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.742
5
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.666
6
UniProt:Q14498 RBM39
1
RBM39 [nucleoplasm]
(R-HSA-9770254)
0.556
3
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:P62875 POLR2L
2
POLR2L [cytosol]
(R-HSA-1964467)
POLR2L [nucleoplasm]
(R-HSA-83715)
0.556
3
UniProt:Q96NC0 ZMAT2
1
ZMAT2 [nucleoplasm]
(R-HSA-9770248)
0.556
3
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:Q9H257 CARD9
3
CARD9 [cytosol]
(R-HSA-561194)
p-T231-CARD9 [plasma membrane]
(R-HSA-5607623)
CARD9 [plasma membrane]
(R-HSA-5607662)
0.556
3
UniProt:P53350 PLK1
4
PLK1 [cytosol]
(R-HSA-164603)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [nucleoplasm]
(R-HSA-156720)
0.508
2
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.508
2
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.508
2
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