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PHC2 [nucleoplasm]
Stable Identifier
R-HSA-389112
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Polyhomeotic-like protein 2, HPH2, EDR2, Early development regulatory protein 2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
PHC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IXK0 PHC2
Gene Names
PHC2, EDR2, PH2
Chain
chain:1-858
Reference Genes
BioGPS Gene:1912 PHC2
COSMIC (genes):PHC2 PHC2
CTD Gene:1912 PHC2
dbSNP Gene:1912 PHC2
ENSEMBL:ENSG00000134686 PHC2
ENSEMBL_homo_sapiens_GENE:ENSG00000134686.21 PHC2
HGNC:3183 PHC2
KEGG Gene (Homo sapiens):1912 PHC2
Monarch:1912 PHC2
NCBI Gene:1912 PHC2
OMIM:602979 PHC2
UCSC:Q8IXK0 PHC2
Reference Transcript
RefSeq:XM_017000518.1 PHC2
RefSeq:XM_005270570.1 PHC2
RefSeq:XM_017000517.1 PHC2
RefSeq:NM_198040.2 PHC2
RefSeq:XM_017000516.1 PHC2
RefSeq:NM_004427.3 PHC2
Other Identifiers
11716870_a_at
11720336_a_at
11745433_a_at
16684870
1912
200919_PM_at
200919_at
2405470
2405471
2405472
2405473
2405474
2405475
2405483
2405484
2405485
2405486
2405488
2405491
2405492
2405493
2405505
2405506
2405512
2405514
2405515
2405516
2405520
2405521
2405523
2405530
2405532
2405533
2405535
2405536
2405537
2405552
2405553
36960_at
7914648
A_23_P34510
A_23_P423864
A_24_P265254
GE59526
GO:0000792
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0007283
GO:0008270
GO:0022414
GO:0031519
GO:0035102
GO:0042802
GO:0043226
GO:0046872
HMNXSV003009393
HMNXSV003046595
Hs.165263.0.A1_3p_at
Hs.165263.0.A1_3p_x_at
ILMN_1670147
ILMN_1673461
ILMN_1808047
PH_hs_0029290
TC01005397.hg
TC01005398.hg
U89278_at
g4758241_3p_at
Participates
as a component of
monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
as a member of
PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
Inferred To
PHC2 [nucleoplasm]
(Bos taurus)
PHC2 [nucleoplasm]
(Canis familiaris)
PHC2 [nucleoplasm]
(Danio rerio)
PHC2 [nucleoplasm]
(Drosophila melanogaster)
PHC2 [nucleoplasm]
(Mus musculus)
PHC2 [nucleoplasm]
(Sus scrofa)
phc2 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of PHC2 [nucleoplasm]
(Gallus gallus)
ph-d [nucleoplasm]
(Drosophila melanogaster)
Phc2 [nucleoplasm]
(Rattus norvegicus)
Homologues of PHC2 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_005270627.1
,
XP_016856005.1
,
NP_932157.1
,
NP_004418.2
,
XP_016856006.1
,
XP_016856007.1
OpenTargets
ENSG00000134686
GeneCards
Q8IXK0
HPA
ENSG00000134686-PHC2
Ensembl
ENSP00000257118
,
ENSP00000507877
,
ENST00000683057
,
ENSP00000362517
,
ENST00000257118
,
ENSG00000134686
,
ENST00000373418
PRO
Q8IXK0
Pharos - Targets
Q8IXK0
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.816
8
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.742
5
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.666
6
UniProt:Q96NC0 ZMAT2
1
ZMAT2 [nucleoplasm]
(R-HSA-9770248)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:P62875 POLR2L
2
POLR2L [nucleoplasm]
(R-HSA-83715)
POLR2L [cytosol]
(R-HSA-1964467)
0.556
3
UniProt:Q14498 RBM39
1
RBM39 [nucleoplasm]
(R-HSA-9770254)
0.556
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.556
3
UniProt:Q9H257 CARD9
3
CARD9 [cytosol]
(R-HSA-561194)
CARD9 [plasma membrane]
(R-HSA-5607662)
p-T231-CARD9 [plasma membrane]
(R-HSA-5607623)
0.556
3
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.508
2
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.508
2
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.508
2
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