Reactome | RING1 [nucleoplasm]

RING1 [nucleoplasm]

Stable Identifier

R-HSA-389113

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase RING1, RNF1, RING1A

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q06587 RING1

Gene Names

RING1, RNF1, RNF1

Chain

chain:1-406

Reference Genes

BioGPS Gene:6015 RING1

COSMIC (genes):RING1 RING1

CTD Gene:6015 RING1

dbSNP Gene:6015 RING1

ENSEMBL:ENSG00000204227 RING1

ENSEMBL_homo_sapiens_GENE:ENSG00000204227.5 RING1

ENSEMBL_homo_sapiens_GENE:ENSG00000206287.5 RING1

ENSEMBL_homo_sapiens_GENE:ENSG00000226788.3 RING1

ENSEMBL_homo_sapiens_GENE:ENSG00000228520.3 RING1

ENSEMBL_homo_sapiens_GENE:ENSG00000231115.3 RING1

ENSEMBL_homo_sapiens_GENE:ENSG00000235107.3 RING1

HGNC:10018 RING1

KEGG Gene (Homo sapiens):6015 RING1

Monarch:6015 RING1

NCBI Gene:6015 RING1

OMIM:602045 RING1

UCSC:Q06587 RING1

Reference Transcript

RefSeq:NM_002931.3 RING1

Other Identifiers

11720071_a_at

11720072_a_at

11748887_a_at

17007406

17028455

17031267

17033752

17036016

17038735

208371_PM_s_at

208371_s_at

2903508

2903509

2903510

2903512

2903514

2903515

2903518

2903519

2903521

2903522

2903523

2903524

35685_PM_at

35685_at

6015

70617_f_at

8118634

8178244

A_24_P200694

GE80158

GO:0000151

GO:0001739

GO:0003682

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0009952

GO:0016567

GO:0016604

GO:0016607

GO:0016740

GO:0031519

GO:0035102

GO:0035518

GO:0036211

GO:0043226

GO:0045892

GO:0046872

GO:0048593

GO:0048856

GO:0061630

GO:0097027

GO:0098772

GO:0140096

HMNXSV003024854

ILMN_1666399

PH_hs_0011914

PH_hs_0040270

TC06000415.hg

TC6_cox_hap2000105.hg

TC6_dbb_hap3000097.hg

TC6_mann_hap4000089.hg

TC6_mcf_hap5000090.hg

TC6_qbl_hap6000096.hg

Z14000_at

g11863157_3p_s_at

Participates

as a component of

as a member of

RING1,RNF2 [nucleoplasm] (Homo sapiens)

Inferred To

spat-3 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of RING1 [nucleoplasm] (Gallus gallus)

Sce [nucleoplasm] (Drosophila melanogaster)

RING1 [nucleoplasm] (Bos taurus)

RING1 [nucleoplasm] (Canis familiaris)

RING1 [nucleoplasm] (Sus scrofa)

ring1 [nucleoplasm] (Xenopus tropicalis)

Ring1 [nucleoplasm] (Mus musculus)

Ring1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_002922.2

OpenTargets

ENSG00000204227

IntEnz

2.3.2.27

GeneCards

Q06587

HPA

ENSG00000204227-RING1

Ensembl

ENSP00000363787, ENSG00000228520, ENST00000374656, ENSG00000235107, ENSG00000231115, ENST00000436128, ENSP00000372699, ENST00000430233, ENST00000383212, ENST00000427374, ENSG00000206287, ENST00000415941, ENSP00000400572, ENSP00000412190, ENSP00000396439, ENSP00000396271, ENSG00000204227, ENSG00000226788

PRO

Q06587

Pharos - Targets

Q06587

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.935	15
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.738	6
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.666	6
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.656	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.65	7
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.643	5
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.643	4
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.643	5
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	3
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	3
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.527	3