Reactome | PCGF2 [nucleoplasm]

PCGF2 [nucleoplasm]

Stable Identifier

R-HSA-389115

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - E2F6 binds the PRC1 complex (Homo sapiens)
        
        E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        BMI1,PCGF2 [nucleoplasm] (Homo sapiens)
        
        PCGF2 [nucleoplasm] (Homo sapiens)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        BMI1,PCGF2 [nucleoplasm] (Homo sapiens)
        
        PCGF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35227 PCGF2

Gene Names

PCGF2, MEL18, RNF110, ZNF144

Chain

chain:1-344

Reference Genes

BioGPS Gene:7703 PCGF2

CTD Gene:7703 PCGF2

dbSNP Gene:7703 PCGF2

ENSEMBL:ENSG00000277258 PCGF2

HGNC:12929 PCGF2

KEGG:hsa:7703 PCGF2

Monarch:7703 PCGF2

NCBI Gene:7703 PCGF2

OMIM:600346 PCGF2

UCSC:P35227 PCGF2

Reference Transcript

Other Identifiers

11718747_at

11744589_a_at

11746154_a_at

16843987

203792_3p_x_at

203792_PM_x_at

203792_x_at

203793_PM_x_at

203793_x_at

213551_PM_x_at

213551_x_at

214239_PM_x_at

214239_x_at

32191_at

32192_g_at

3755324

3755325

3755326

3755327

3755328

3755329

3755330

3755331

3755332

3755333

3755335

3755336

3755337

3755338

3755339

3755343

3755344

3755346

3755347

3755348

3755351

3755352

3755353

3755354

55300_f_at

69148_s_at

7703

8014706

D13969_at

GE62100

GE79138

GO:0000122

GO:0000785

GO:0001701

GO:0001739

GO:0003677

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006338

GO:0006355

GO:0009952

GO:0016604

GO:0031519

GO:0035102

GO:0043226

GO:0046872

GO:0048704

GO:0048706

GO:0048856

GO:0070301

GO:0097190

GO:1990841

GO:2001234

HMNXSV003000906

Hs.184669.3.S1_3p_a_at

ILMN_1809859

PH_hs_0032931

TC17001430.hg

g13436061_3p_a_at

g6005963_3p_a_at

Participates

as a component of

as an output of

Retinoic acid activates HOXD4 chromatin (Homo sapiens)

as a member of

BMI1,PCGF2 [nucleoplasm] (Homo sapiens)

Inferred To

Pcgf2 [nucleoplasm] (Mus musculus)

Psc [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of PCGF2 [nucleoplasm] (Xenopus tropicalis)

PCGF2 [nucleoplasm] (Bos taurus)

PCGF2 [nucleoplasm] (Canis familiaris)

PCGF2 [nucleoplasm] (Gallus gallus)

PCGF2 [nucleoplasm] (Rattus norvegicus)

PCGF2 [nucleoplasm] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000488868, ENST00000610440, ENSP00000478517, ENST00000611883, ENSP00000488872, ENST00000616199, ENST00000631610, ENST00000620225, ENSP00000478970, ENST00000631566, ENSP00000482815, ENSP00000482063

OpenTargets

ENSG00000277258

HPA

ENSG00000277258-PCGF2

PRO

P35227

Pharos - Targets

P35227

GlyGen

P35227

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.945	18
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.935	15
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.926	13
UniProt:P78364 PHC1	1	PHC1 [nucleoplasm] (R-HSA-389111)	0.916	13
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.858	10
UniProt:O95931 CBX7			0.839	8
UniProt:Q14781 CBX2	1	CBX2 [nucleoplasm] (R-HSA-389110)	0.788	6
UniProt:O00257 CBX4	2	monoSUMO1-K494-CBX4 [nucleoplasm] (R-HSA-4551626) CBX4 [nucleoplasm] (R-HSA-389118)	0.788	7
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.759	5
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.725	6
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.725	7
UniProt:Q8NDX5 PHC3	1	PHC3 [nucleoplasm] (R-HSA-389116)	0.725	6
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.69	4
UniProt:P30279 CCND2	2	CCND2 [cytosol] (R-HSA-68340) CCND2 [nucleoplasm] (R-HSA-113827)	0.592	4
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.591	5
UniProt:P51784 USP11	1	USP11 [cytosol] (R-HSA-391303)	0.591	5
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q9HAT8 PELI2	2	PELI2 [cytosol] (R-HSA-450694) p-PELI2 [cytosol] (R-HSA-450825)	0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q96GA3 LTV1	2	LTV1 [cytosol] (R-HSA-6791520) LTV1 [nucleoplasm] (R-HSA-6791566)	0.527	2
UniProt:Q5H9F3 BCORL			0.527	2
UniProt:Q8VDS3 CBX7			0.527	2
UniProt:Q14249 NUCG			0.527	2
UniProt:Q9H0H3 KLHL25	1	KLHL25 [cytosol] (R-HSA-8863189)	0.527	2
UniProt:Q9P0J1 PDP1	1	PDP1 [mitochondrial matrix] (R-HSA-204149)	0.527	2
UniProt:Q96GD3 SCMH1			0.527	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.499	2
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.499	2

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