Reactome | PHC3 [nucleoplasm]

PHC3 [nucleoplasm]

Stable Identifier

R-HSA-389116

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - E2F6 binds the PRC1 complex (Homo sapiens)
        
        E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        PHC1,PHC3 [nucleoplasm] (Homo sapiens)
        
        PHC3 [nucleoplasm] (Homo sapiens)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        PHC1,PHC3 [nucleoplasm] (Homo sapiens)
        
        PHC3 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
        
        PHC3 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        PHC1,PHC2,PHC3 [nucleoplasm] (Homo sapiens)
        
        PHC3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NDX5 PHC3

Gene Names

PHC3, EDR3, PH3

Chain

chain:1-983

Reference Genes

BioGPS Gene:80012 PHC3

COSMIC (genes):PHC3 PHC3

CTD Gene:80012 PHC3

dbSNP Gene:80012 PHC3

ENSEMBL:ENSG00000173889 PHC3

ENSEMBL_homo_sapiens_GENE:ENSG00000173889.16 PHC3

HGNC:15682 PHC3

KEGG Gene (Homo sapiens):80012 PHC3

Monarch:80012 PHC3

NCBI Gene:80012 PHC3

OMIM:620031 PHC3

UCSC:Q8NDX5 PHC3

Reference Transcript

Other Identifiers

11722279_a_at

11722280_at

11722281_a_at

11747142_a_at

11752039_a_at

11752040_s_at

11759919_at

11759920_at

1552644_PM_a_at

1552644_a_at

16961420

220328_PM_at

220328_at

226508_PM_at

226508_at

238693_PM_at

238693_at

2704883

2704885

2704887

2704889

2704891

2704893

2704895

2704896

2704897

2704898

2704899

2704900

2704901

2704902

2704906

2704908

2704909

2704910

2704912

2704913

2704916

2704917

2704920

2704925

2704927

2704928

2704932

2704933

2704934

2704935

2704937

2704940

2704941

2704945

2704947

43936_at

57819_at

66503_at

80012

8092035

87668_at

A_23_P409988

A_24_P265177

A_33_P3400324

GE691709

GE83015

GE88636

GO:0003677

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0008270

GO:0031519

GO:0032991

GO:0035102

GO:0042393

GO:0043226

GO:0045892

GO:0046872

HMNXSV003046344

HMNXSV003046737

Hs.25328.0.A1_3p_at

Hs.97042.0.A1_3p_at

Hs2.231977.1.S1_3p_a_at

ILMN_2179873

TC03001988.hg

TC03003204.hg

g13489102_3p_at

Participates

as a component of

as a member of

Inferred To

phc3 [nucleoplasm] (Xenopus tropicalis)

Homologues of PHC3 [nucleoplasm] (Drosophila melanogaster)

Phc3 [nucleoplasm] (Rattus norvegicus)

ph-d [nucleoplasm] (Drosophila melanogaster)

PHC3 [nucleoplasm] (Bos taurus)

PHC3 [nucleoplasm] (Canis familiaris)

PHC3 [nucleoplasm] (Drosophila melanogaster)

PHC3 [nucleoplasm] (Gallus gallus)

PHC3 [nucleoplasm] (Mus musculus)

PHC3 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001295045.1, NP_079223.3

OpenTargets

ENSG00000173889

HPA

ENSG00000173889-PHC3

GeneCards

Q8NDX5

Ensembl

ENST00000494943, ENSP00000420271, ENST00000497658, ENSG00000173889, ENSP00000420454, ENSP00000420294, ENST00000495893

PRO

Q8NDX5

Pharos - Targets

Q8NDX5

PDB

4PZN, 4PZO

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.643	4
UniProt:O15294 OGT	2	OGT [nucleoplasm] (R-HSA-3321845) OGT [cytosol] (R-HSA-9687814)	0.556	3
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.483	2

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