Reactome | CBX4 [nucleoplasm]

CBX4 [nucleoplasm]

Stable Identifier

R-HSA-389118

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX4 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX4 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN gene transcription (Homo sapiens)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX4 [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX4 [nucleoplasm] (Homo sapiens)
        
        PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX4 [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00257 CBX4

Gene Names

CBX4

Chain

chain:1-560

Reference Genes

BioGPS Gene:8535 CBX4

COSMIC (genes):CBX4 CBX4

CTD Gene:8535 CBX4

dbSNP Gene:8535 CBX4

ENSEMBL:ENSG00000141582 CBX4

HGNC:1554 CBX4

KEGG:hsa:8535 CBX4

Monarch:8535 CBX4

NCBI Gene:8535 CBX4

OMIM:603079 CBX4

UCSC:O00257 CBX4

Reference Transcript

RefSeq:NM_003655.3 CBX4

Participates

as a member of

as a component of

monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K494-CBX4 [nucleoplasm]

Inferred To

Cbx4 [nucleoplasm] (Mus musculus)

Cbx4 [nucleoplasm] (Rattus norvegicus)

cbx4 [nucleoplasm] (Xenopus tropicalis)

cbx7a [nucleoplasm] (Danio rerio)

CBX4 [nucleoplasm] (Bos taurus)

CBX4 [nucleoplasm] (Canis familiaris)

CBX4 [nucleoplasm] (Gallus gallus)

CBX4 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_003646.2

ENSEMBL

ENST00000269397, ENSP00000269397, ENSG00000141582

OpenTargets

ENSG00000141582

GeneCards

CBX4

HPA

ENSG00000141582-CBX4

ZINC - Substances

CBX4_HUMAN

ZINC target

O00257

PRO

O00257

Pharos - Targets

O00257

ZINC - Predictions - Purchasable

CBX4_HUMAN

PDB

2K28, 3I8Z, 5EPL

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.837	8
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.706	4
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.695	5
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105)	0.674	15
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.604	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.602	4