CD28 bound PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-389158
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PI3K enzyme bound to co-stimulatory protein CD28 catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB.

Literature References
PubMed ID Title Journal Year
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of CD28:PI3K [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created