Reactome | SMARCA2 [nucleoplasm]

SMARCA2 [nucleoplasm]

Stable Identifier

R-HSA-389256

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hBrm

Locations in the PathwayBrowser for interactor UniProt:P14921 ETS1

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External Reference Information

External Reference

UniProt:P51531 SMARCA2

Gene Names

SMARCA2, BAF190B, BRM, SNF2A, SNF2L2

Chain

chain:1-1590

Reference Genes

BioGPS Gene:6595 SMARCA2

COSMIC (genes):SMARCA2 SMARCA2

CTD Gene:6595 SMARCA2

dbSNP Gene:6595 SMARCA2

ENSEMBL:ENSG00000080503 SMARCA2

HGNC:11098 SMARCA2

KEGG:hsa:6595 SMARCA2

Monarch:6595 SMARCA2

NCBI Gene:6595 SMARCA2

OMIM:600014 SMARCA2

UCSC:P51531 SMARCA2

Reference Transcript

Participates

as an input of

Formation of neuronal progenitor BAF (npBAF) (Homo sapiens)

as a member of

SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)

Inferred To

Smarca2 [nucleoplasm] (Rattus norvegicus)

smarca2 [nucleoplasm] (Xenopus tropicalis)

Homologues of SMARCA2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SMARCA2 [nucleoplasm] (Dictyostelium discoideum)

Homologues of SMARCA2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of SMARCA2 [nucleoplasm] (Schizosaccharomyces pombe)

pqn-15 [nucleoplasm] (Caenorhabditis elegans)

SMARCA2 [nucleoplasm] (Bos taurus)

SMARCA2 [nucleoplasm] (Caenorhabditis elegans)

SMARCA2 [nucleoplasm] (Canis familiaris)

SMARCA2 [nucleoplasm] (Dictyostelium discoideum)

SMARCA2 [nucleoplasm] (Drosophila melanogaster)

SMARCA2 [nucleoplasm] (Gallus gallus)

SMARCA2 [nucleoplasm] (Mus musculus)

SMARCA2 [nucleoplasm] (Saccharomyces cerevisiae)

SMARCA2 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

Guide to Pharmacology - Targets

2739

OpenTargets

ENSG00000080503

ENSEMBL

ENST00000382194, ENST00000349721, ENST00000382203, ENST00000357248, ENSP00000349788, ENSG00000080503, ENSP00000371638, ENSP00000265773, ENSP00000371629

HPA

ENSG00000080503-SMARCA2

GeneCards

SMARCA2

ZINC - Substances

SMCA2_HUMAN

ZINC target

P51531

PRO

P51531

Pharos - Targets

P51531

Orphanet

SMARCA2

GlyGen

P51531

PDB

7Z6L, 8G1P, 7S4E, 4QY4, 7Z78, 7Z77, 6HAY, 6HAZ, 5DKC, 6HAX, 5DKH, 8QJT, 7Z76, 2DAT, 6EG3, 6EG2

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.848	12
UniProt:O14497 ARID1A	1	ARID1A [nucleoplasm] (R-HSA-389259)	0.757	6
UniProt:Q8NFD5 ARID1B	1	ARID1B [nucleoplasm] (R-HSA-5225635)	0.688	4
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.643	5
UniProt:Q92785 DPF2	1	DPF2 [nucleoplasm] (R-HSA-9727509)	0.643	5
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.632	4
UniProt:P04326 TAT			0.602	8
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.592	2
UniProt:Q9UHA2 S18L2			0.569	5
UniProt:P14921 ETS1	2	p-T38-ETS1 [nucleoplasm] (R-HSA-3132720) ETS1 [nucleoplasm] (R-HSA-1629809)	0.536	2
UniProt:Q92784-1 DPF3			0.527	4
UniProt:Q92784-2 DPF3			0.527	5
UniProt:Q8WUZ0 BCL7C	1	BCL7C [nucleoplasm] (R-HSA-9727457)	0.527	4
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.527	4
UniProt:Q92782 DPF1	1	DPF1 [nucleoplasm] (R-HSA-8855001)	0.527	3
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.524	2
UniProt:P51608 MECP2			0.524	4
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.508	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2
UniProt:A4PIW0 A4PIW0			0.462	2

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