Reactome | SMARCE1 [nucleoplasm]

SMARCE1 [nucleoplasm]

Stable Identifier

R-HSA-389258

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BAF57

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds the SWI/SNF complex (Homo sapiens)
        
        RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SWI/SNF additional components [nucleoplasm] (Homo sapiens)
        
        SMARCE1 [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SWI/SNF additional components [nucleoplasm] (Homo sapiens)
        
        SMARCE1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q969G3 SMARCE1

Gene Names

SMARCE1, BAF57

Chain

chain:1-411

Reference Genes

BioGPS Gene:6605 SMARCE1

COSMIC (genes):SMARCE1 SMARCE1

CTD Gene:6605 SMARCE1

dbSNP Gene:6605 SMARCE1

ENSEMBL:ENSG00000073584 SMARCE1

HGNC:11109 SMARCE1

KEGG Gene (Homo sapiens):6605 SMARCE1

Monarch:6605 SMARCE1

NCBI Gene:6605 SMARCE1

OMIM:603111 SMARCE1

UCSC:Q969G3 SMARCE1

Reference Transcript

RefSeq:NM_003079.4 SMARCE1

Other Identifiers

0002510632

11718772_at

11718773_s_at

11718774_s_at

11752770_a_at

11754075_s_at

11761728_a_at

16844386

16844406

211988_at

211989_at

236016_at

2963127

33828_at

3487942

3756345

3756346

3756347

3756348

3756349

3756350

3756351

3756352

3756353

3756355

3756356

3756358

3756363

3756364

3756365

3756371

3756375

3756376

3756378

3756379

3756380

3756381

3756382

6605

74367_at

77132_at

8015037

8015039

A_23_P164387

A_23_P333063

A_32_P20221

GE558638

GE79213

GO:0000228

GO:0000790

GO:0000978

GO:0003674

GO:0003677

GO:0003682

GO:0003713

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006337

GO:0006338

GO:0006357

GO:0007399

GO:0008080

GO:0008134

GO:0008150

GO:0009058

GO:0016514

GO:0016746

GO:0016922

GO:0022008

GO:0030154

GO:0031492

GO:0032991

GO:0034641

GO:0043044

GO:0043226

GO:0045892

GO:0047485

GO:0048856

GO:0051276

GO:0071564

GO:0071565

GO:1903508

Hs.127211.0.A1_3p_at

Hs.332848.0.S1_3p_at

Hs.332848.0.S2_3p_at

ILMN_1747857

PH_hs_0030249

PH_hs_0033412

TC17002900.hg

Participant Of

hasCandidate

SWI/SNF additional components [nucleoplasm]

Inferred To

smarce1 [nucleoplasm] (Danio rerio)

smarce1 [nucleoplasm] (Xenopus tropicalis)

swsn-3 [nucleoplasm] (Caenorhabditis elegans)

SMARCE1 [nucleoplasm] (Canis familiaris)

SMARCE1 [nucleoplasm] (Gallus gallus)

SMARCE1 [nucleoplasm] (Sus scrofa)

Bap111 [nucleoplasm] (Drosophila melanogaster)

Smarce1 [nucleoplasm] (Mus musculus)

Smarce1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_003070.3

OpenTargets

ENSG00000073584

HPA

ENSG00000073584-SMARCE1

GeneCards

Q969G3

Ensembl

ENSP00000392958, ENSP00000464511, ENST00000264640, ENST00000578044, ENST00000644701, ENST00000647508, ENST00000643318, ENSP00000411607, ENSP00000496097, ENST00000348513, ENSP00000494771, ENSP00000323967, ENSP00000496445, ENSP00000466608, ENST00000447024, ENSP00000496094, ENSP00000367039, ENSG00000073584, ENST00000643683, ENST00000400122, ENST00000377808

PRO

Q969G3

Orphanet

22035

PDB

6LTJ, 6LTH

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.643	4
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.556	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.556	3
UniProt:Q9UPT5 EXOC7	2	EXOC7 [cytosol] (R-HSA-5623386) EXOC7 [plasma membrane] (R-HSA-2872288)	0.556	5
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:Q13099 IFT88	8	PolyUb-Misfolded IFT88 [lysosomal lumen] (R-HSA-9660026) IFT88 [ciliary tip] (R-HSA-5625371) PolyUb-Misfolded IFT88 [cytosol] (R-HSA-9641125) Ub-Misfolded IFT88 [cytosol] (R-HSA-9641114) Misfolded IFT88 [cytosol] (R-HSA-9640115) Misfolded IFT88 [cilium] (R-HSA-9640106) IFT88 [cilium] (R-HSA-5610385) PolyUb-Misfolded IFT88 [late endosome lumen] (R-HSA-9660031)	0.556	3
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2