Reactome | SMARCB1 [nucleoplasm]

SMARCB1 [nucleoplasm]

Stable Identifier

R-HSA-389261

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Snf5, INI1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds the SWI/SNF complex (Homo sapiens)
        
        RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm] (Homo sapiens)
        
        SMARCB1 [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm] (Homo sapiens)
        
        SMARCB1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12824 SMARCB1

Gene Names

SMARCB1, BAF47, INI1, SNF5L1

Chain

chain:1-385

Reference Genes

BioGPS Gene:6598 SMARCB1

COSMIC (genes):SMARCB1 SMARCB1

CTD Gene:6598 SMARCB1

dbSNP Gene:6598 SMARCB1

ENSEMBL:ENSG00000099956 SMARCB1

ENSEMBL:ENSG00000275837 SMARCB1

HGNC:11103 SMARCB1

KEGG Gene (Homo sapiens):6598 SMARCB1

Monarch:6598 SMARCB1

NCBI Gene:6598 SMARCB1

OMIM:601607 SMARCB1

UCSC:Q12824 SMARCB1

Reference Transcript

Other Identifiers

0004210603

11745213_a_at

11753187_a_at

11755155_x_at

16928046

18248

19127

212167_s_at

228898_s_at

229719_s_at

3939377

3939378

3939379

3939380

3939382

3939383

3939384

3939388

3939389

3939397

3939399

3939403

3939405

3939406

3939407

3939408

3939409

3939410

3939411

3939412

3939413

3939414

3939415

40416_at

5AJ1

5GJK

5L7A

5L7B

6598

6AX5

8071768

90507_at

9196

A0A0G2JRV3

A0A0G2JSE9

A0A2R8Y5N5

A0A2R8Y5Z2

A0A2R8YDN6

A0A2R8YEE8

A_14_P111527

A_23_P68824

A_33_P3232508

A_33_P3343073

AAA81905

AAI17115

AAI43668

AB017523

ABB02184

AJ011737

AJ011738

AK021419

B5MCL5

BAC77068

BAG51033

BC117114

BC143667

C9JTA6

CAA09758

CAA09759

CAA76639

CAB009196

CAG30467

CCDS13817

CCDS46671

CH471095

CR456581

DQ230988

EAW59606

ENSG00000099956

ENSG00000275837

ENSP00000383984

ENSP00000479330

ENSP00000486870

ENSP00000494049

ENST00000407422

ENST00000407422.8

ENST00000618915

ENST00000631333

ENST00000644036

ENST00000644036.1

EntrezGene:6598

EntrezGene:SMARCB1

G5E975

GE62285

GO:0000228

GO:0000790

GO:0000978

GO:0000980

GO:0001164

GO:0001188

GO:0001650

GO:0002039

GO:0003674

GO:0003677

GO:0003713

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006259

GO:0006325

GO:0006337

GO:0006338

GO:0006357

GO:0006464

GO:0007049

GO:0007165

GO:0007399

GO:0008134

GO:0008150

GO:0009058

GO:0015074

GO:0016032

GO:0016514

GO:0022607

GO:0030957

GO:0031492

GO:0032991

GO:0034641

GO:0035060

GO:0039692

GO:0042592

GO:0043044

GO:0043226

GO:0043231

GO:0043923

GO:0044403

GO:0045944

GO:0048856

GO:0051091

GO:0051276

GO:0065003

GO:0071564

GO:0071565

GO:0090240

GO:1900110

GO:1900113

GO:1901838

GO:1902661

GO:2000617

HGNC:11103

HPA018248

HPA019127

Hs.14587.1.A1_3p_a_at

Hs.14587.2.S1_3p_a_at

Hs.159971.2.A1_3p_a_at

ILMN_1758823

ILMN_2403458

IPR006939

IPR017393

LRG_520

MIM:162091

MIM:601607

MIM:609322

MIM:614608

NM_001007468

NM_003073

NP_001007469

NP_003064

PF04855

PH_hs_0026820

SMARCB1

SMARCB1-204

SMARCB1-213

SMARCB1-222

SMARCB1-228

TC22000139.hg

U04847

UPI00000019FA

UPI000002B3E2

Y17118

Y17119

Y17120

Y17121

Y17122

Y17123

Y17124

Y17125

Y17126

Participant Of

hasComponent

SMARCA2,SMARCA4:SMARCB1:SMARCC1:SMARCC2 [nucleoplasm]

Inferred To

Ghost homologue of SMARCB1 [nucleoplasm] (Plasmodium falciparum)

SMARCB1 [nucleoplasm] (Bos taurus)

SMARCB1 [nucleoplasm] (Caenorhabditis elegans)

SMARCB1 [nucleoplasm] (Canis familiaris)

SMARCB1 [nucleoplasm] (Danio rerio)

SMARCB1 [nucleoplasm] (Dictyostelium discoideum)

SMARCB1 [nucleoplasm] (Drosophila melanogaster)

SMARCB1 [nucleoplasm] (Gallus gallus)

SMARCB1 [nucleoplasm] (Mus musculus)

SMARCB1 [nucleoplasm] (Rattus norvegicus)

SMARCB1 [nucleoplasm] (Saccharomyces cerevisiae)

SMARCB1 [nucleoplasm] (Schizosaccharomyces pombe)

SMARCB1 [nucleoplasm] (Sus scrofa)

SMARCB1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_003064.2, NP_001007469.1

OpenTargets

ENSG00000099956

GeneCards

Q12824

PRO

Q12824

Orphanet

15526

PDB

5GJK, 5L7A, 5L7B, 5AJ1, 6AX5

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.868	26
UniProt:P27797 CALR	6	CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905)	0.613	5
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.524	3
UniProt:Q8K1P7	1	SMARCA4 [nucleoplasm] (R-RNO-201686)	0.499	2
UniProt:P07237 P4HB	3	HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287) P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902)	0.462	4
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.462	4
UniProt:P51991 HNRNPA3	1	HNRNPA3 [nucleoplasm] (R-HSA-71931)	0.462	4
UniProt:P30101 PDIA3	3	PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.462	4
UniProt:P14625 HSP90B1	4	HSP90B1 [extracellular region] (R-HSA-3221653) HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.462	4
UniProt:O43852 CALU	3	p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [extracellular region] (R-HSA-350739) CALU [endoplasmic reticulum lumen] (R-HSA-350695)	0.462	4
UniProt:O43819 SCO2	1	SCO2 [mitochondrial matrix] (R-HSA-5336150)	0.462	3
UniProt:Q00059 TFAM	2	TFAM [mitochondrial matrix] (R-HSA-163312) TFAM(1-246) [cytosol] (R-HSA-1592203)	0.462	3
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.462	4
UniProt:P22061 PCMT1	1	PCMT1 [cytosol] (R-HSA-5676580)	0.462	4
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.462	3
UniProt:P55735 SEC13	4	SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [lysosomal membrane] (R-HSA-9638246)	0.462	4
UniProt:Q9NPI1 BRD7	1	BRD7 [nucleoplasm] (R-HSA-3222092)	0.462	4
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2