Reactome | SMARCB1 [nucleoplasm]

SMARCB1 [nucleoplasm]

Stable Identifier

R-HSA-389261

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Snf5, INI1

Locations in the PathwayBrowser for interactor UniProt:Q53GS7 GLE1

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External Reference Information

External Reference

UniProt:Q12824 SMARCB1

Gene Names

SMARCB1, BAF47, INI1, SNF5L1

Chain

chain:1-385

Reference Genes

BioGPS Gene:6598 SMARCB1

COSMIC (genes):SMARCB1 SMARCB1

CTD Gene:6598 SMARCB1

dbSNP Gene:6598 SMARCB1

ENSEMBL:ENSG00000099956 SMARCB1

HGNC:11103 SMARCB1

KEGG:hsa:6598 SMARCB1

Monarch:6598 SMARCB1

NCBI Gene:6598 SMARCB1

OMIM:601607 SMARCB1

UCSC:Q12824 SMARCB1

Reference Transcript

Participates

as a component of

as an input of

Inferred To

sfh1 [nucleoplasm] (Schizosaccharomyces pombe)

snfc-5 [nucleoplasm] (Caenorhabditis elegans)

SFH1 [nucleoplasm] (Saccharomyces cerevisiae)

smarcb1a [nucleoplasm] (Danio rerio)

Smarcb1 [nucleoplasm] (Mus musculus)

Smarcb1 [nucleoplasm] (Rattus norvegicus)

smarcb1 [nucleoplasm] (Xenopus tropicalis)

SMARCB1 [nucleoplasm] (Bos taurus)

SMARCB1 [nucleoplasm] (Canis familiaris)

SMARCB1 [nucleoplasm] (Dictyostelium discoideum)

SMARCB1 [nucleoplasm] (Gallus gallus)

SMARCB1 [nucleoplasm] (Sus scrofa)

Snr1 [nucleoplasm] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000099956

ENSEMBL

ENSP00000479330, ENSP00000486870, ENSP00000383984, ENST00000407422, ENST00000631333, ENSG00000099956, ENST00000644036, ENSP00000494049, ENSG00000275837, ENST00000618915

GeneCards

SMARCB1

HPA

ENSG00000099956-SMARCB1

PRO

Q12824

Pharos - Targets

Q12824

GlyGen

Q12824

Orphanet

SMARCB1

PDB

5L7A, 5L7B, 6AX5, 6LTH, 6UCH, 6LZP, 6LTJ, 6KZ7, 5AJ1, 5GJK, 7VDV, 6KAG, 7Y8R

Interactors (59)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.953	39
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.919	19
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.894	14
UniProt:Q68CP9 ARID2	1	ARID2 [nucleoplasm] (R-HSA-5225613)	0.89	14
UniProt:Q8NFD5 ARID1B	1	ARID1B [nucleoplasm] (R-HSA-5225635)	0.886	15
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.886	16
UniProt:O14497 ARID1A	1	ARID1A [nucleoplasm] (R-HSA-389259)	0.864	18
UniProt:Q15532 SS18	1	SS18 [nucleoplasm] (R-HSA-9727441)	0.864	15
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.848	16
UniProt:Q8WUB8 PHF10	1	PHF10 [nucleoplasm] (R-HSA-9932814)	0.848	11
UniProt:Q92785 DPF2	1	DPF2 [nucleoplasm] (R-HSA-9727509)	0.848	14
UniProt:P51531 SMARCA2	1	SMARCA2 [nucleoplasm] (R-HSA-389256)	0.848	12
UniProt:Q92925 SMARCD2	1	SMARCD2 [nucleoplasm] (R-HSA-5225626)	0.848	14
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.848	15
UniProt:Q9NPI1 BRD7	1	BRD7 [nucleoplasm] (R-HSA-3222092)	0.802	10
UniProt:Q6STE5 SMARCD3	1	SMARCD3 [nucleoplasm] (R-HSA-400141)	0.788	8
UniProt:Q4VC05 BCL7A	1	BCL7A [nucleoplasm] (R-HSA-9727449)	0.745	10
UniProt:Q92782 DPF1	1	DPF1 [nucleoplasm] (R-HSA-8855001)	0.745	8
UniProt:Q8WUZ0 BCL7C	1	BCL7C [nucleoplasm] (R-HSA-9727457)	0.745	11
UniProt:Q86U86 PBRM1	1	PBRM1 [nucleoplasm] (R-HSA-389254)	0.745	9
UniProt:Q92784 DPF3	1	DPF3 [nucleoplasm] (R-HSA-9727469)	0.725	7
UniProt:Q9BQE9 BCL7B	1	BCL7B [nucleoplasm] (R-HSA-9727463)	0.671	8
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.666	4
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.666	4
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.594	5
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.594	5
UniProt:O60814 H2BC12	9	HIST1H2BK [nucleoplasm] (R-HSA-181898) Ub-121-HIST1H2BK [nucleoplasm] (R-HSA-3364019) AcK21-HIST1H2BK [nucleoplasm] (R-HSA-4568711) AcK13-HIST1H2BK [nucleoplasm] (R-HSA-4568723) AcK16-HIST1H2BK [nucleoplasm] (R-HSA-4568717) AcK6-HIST1H2BK [nucleoplasm] (R-HSA-4568714) HIST1H2BK [extracellular region] (R-HSA-977574) AcK-HIST1H2BK [nucleoplasm] (R-HSA-4549262) Ub-HIST1H2BK [nucleoplasm] (R-HSA-6782548)	0.576	5
UniProt:Q6FI13 H2AC18	13	HIST2H2AA3 [nucleoplasm] (R-HSA-181891) AcK-HIST2H2AA3 [nucleoplasm] (R-HSA-4551317) HIST2H2AA3 [extracellular region] (R-HSA-977587) MeR12-HIST2H2AA3 [nucleoplasm] (R-HSA-5229218) Me2aR12-HIST2H2AA3 [nucleoplasm] (R-HSA-5229295) Me2sR4-HIST2H2AA3 [nucleoplasm] (R-HSA-5218313) MeR4-HIST2H2AA3 [nucleoplasm] (R-HSA-5244610) Me2aR4-HIST2H2AA3 [nucleoplasm] (R-HSA-5244615) MeR30-HIST2H2AA3 [nucleoplasm] (R-HSA-5244534) Me2aR30-HIST2H2AA3 [nucleoplasm] (R-HSA-5244573) AcK6-HIST2H2AA3 [nucleoplasm] (R-HSA-4568606) Ub-HIST2H2AA3 [nucleoplasm] (R-HSA-6782525) K63polyUb-HIST2H2AA3 [nucleoplasm] (R-HSA-6783291)	0.576	5
UniProt:Q96TA2 YME1L1	1	YME1L1 [mitochondrial inner membrane] (R-HSA-8949648)	0.569	5
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:O14656-2 TOR1A			0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) HRAS [plasma membrane] (R-HSA-62717) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) proHRAS [cytosol] (R-HSA-9647765) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:Q9BRK4 LZTS2			0.547	2
UniProt:P04326 TAT			0.544	3
UniProt:O75177 SS18L1	1	SS18L1 [nucleoplasm] (R-HSA-9727481)	0.527	4
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.527	2
UniProt:A3KMH1 VWA8			0.527	3
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.524	3
UniProt:P04585-PRO_0000042447 GAG-POL			0.508	3
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.499	5
UniProt:Q8K1P7 Smarca4	2	Smarca4 [nucleoplasm] (R-RNO-9614783) SMARCA4 [nucleoplasm] (R-RNO-201686)	0.499	2
UniProt:Q9H1E3 NUCKS			0.483	3
UniProt:P09543 CN37			0.483	3
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2

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