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LCK, FYN [cytosol]
Stable Identifier
R-HSA-389329
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Lck/Fyn
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of Cdc42 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Activation of Rac1 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Activation of Vav1 (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Grb2 binds CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Translocation of Vav1 to CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Gads binds CD28 (Homo sapiens)
CD28:GRAP2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Phosphorylation of CD28 (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
LCK, FYN [cytosol] (Homo sapiens)
Participants
members
FYN [cytosol] (Homo sapiens)
LCK [cytosol] (Homo sapiens)
Participant Of
input
Phosphorylation of CD28
hasComponent
phospho CD28:B7-1/B7-2 [plasma membrane]
Inferred To
LCK, FYN [cytosol] (Danio rerio)
LCK, FYN [cytosol] (Sus scrofa)
LCK, FYN [cytosol] (Xenopus tropicalis)
FYN,LCK [cytosol] (Bos taurus)
FYN,LCK [cytosol] (Canis familiaris)
FYN,LCK [cytosol] (Mus musculus)
FYN,LCK [cytosol] (Rattus norvegicus)
Ghost homologue of LCK, FYN [cytosol] (Gallus gallus)
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