Activation of Rac1 by pVav1

Stable Identifier
R-HSA-389348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of Rac1 by pVav1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Vav1, once activated by PIP3 binding and phosphorylation by Fyn, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.
Literature References
PubMed ID Title Journal Year
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE

Nature 1997
9438848 Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

White, MA, Falck, JR, Mosteller, RD, Xia, Y, Han, J, Shu, X, Das, B, Luby-Phelps, K, Krishna, UM, Broek, D

Science 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]

Physical Entity
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of Rac1 by pVav1 (Bos taurus)
Activation of Rac1 by pVav1 (Canis familiaris)
Activation of Rac1 by pVav1 (Gallus gallus)
Activation of Rac1 by pVav1 (Mus musculus)
Activation of Rac1 by pVav1 (Rattus norvegicus)
Activation of Rac1 by pVav1 (Sus scrofa)
Activation of Rac1 by pVav1 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-06)
Cite Us!