CD28 co-stimulation

Stable Identifier
R-HSA-389356
Type
Pathway
Species
Homo sapiens
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In naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation of an antiapoptotic program. CD28 engages with one or both members of the B7 receptor family, B7.1 and B7.2. Upon ligand binding the tyrosines and proline-rich motifs present in the cytoplasmic tail of CD28 are phosphorylated by Lck or Fyn. Upon phosphorylation CD28 recruits and induces phosphorylation and activation of a more restricted set of intracellular signaling components that, together with those mobilized by the TCR, contribute to convert membrane-based biochemical and biophysical changes into gene activation events. Proteins like PI3K, Vav-1, Tec and Itk kinases, AKT, and the Dok-1 adaptor have been identified as elements of the CD28 signaling pathway by biochemical or genetic approaches or both.

Literature References
PubMed ID Title Journal Year
12165654 CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

Michel, F, Acuto, O

Sci STKE 2002
8649453 Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis

Truneh, A, Reddy, M, Ryan, P, Lyn, SD, Eichman, C, Couez, D, Hurle, MR, Sekaly, RP, Olive, D, Sweet, R

Mol Immunol 1996
8609386 Interactions of CD80 and CD86 with CD28 and CTLA4

Ellis, JH, Burden, MN, Vinogradov, DV, Linge, C, Crowe, JS

J Immunol 1996
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