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CD28 dependent PI3K/Akt signaling
Stable Identifier
R-HSA-389357
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
General
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PI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors (CD28), cytokine receptors and chemokine receptors. However, the specific roles of PI3Ks downstream of these receptors vary. CD28 contains the YMNM consensus PI3K-binding motif, and PI3K recruitment by CD28 contributes to or complements TCR-dependent PI3K signaling. Activation of PI3K promotes PIP3 production at the plasma membrane and several potential target molecules for this phospholipid have been implicated in PI3K pathways downstream of the TcR and CD28. Of these targets, at least Vav and Akt have been implicated in CD28 costimulation of T cell activation. AKT/PKB connects PI3K to signaling pathways that promote cytokine transcription, survival, cell-cycle entry and growth.
Literature References
PubMed ID
Title
Journal
Year
15046602
Phosphoinositide 3-kinase in T cell activation and survival
Emery, JL
,
Vanhaesebroeck, B
,
Bilancio, A
,
Okkenhaug, K
Biochem Soc Trans
2004
12670391
The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3
Kane, LP
,
Weiss, A
Immunol Rev
2003
Participants
Events
PI3K binds CD28
(Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3
(Homo sapiens)
PIP3 recruits PDPK1 to the membrane
(Homo sapiens)
PIP3 recruits AKT to the membrane
(Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473
(Homo sapiens)
AKT binds PDPK1
(Homo sapiens)
PDPK1 phosphorylates AKT at T308
(Homo sapiens)
AKT interacts and phosphorylates Cot
(Homo sapiens)
p-S400-Cot phosphorylates NIK
(Homo sapiens)
Participates
as an event of
CD28 co-stimulation (Homo sapiens)
Orthologous Events
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 dependent PI3K/Akt signaling (Caenorhabditis elegans)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Danio rerio)
CD28 dependent PI3K/Akt signaling (Dictyostelium discoideum)
CD28 dependent PI3K/Akt signaling (Drosophila melanogaster)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
CD28 dependent PI3K/Akt signaling (Plasmodium falciparum)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Saccharomyces cerevisiae)
CD28 dependent PI3K/Akt signaling (Schizosaccharomyces pombe)
CD28 dependent PI3K/Akt signaling (Sus scrofa)
CD28 dependent PI3K/Akt signaling (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000175
,
BIOMD0000000255
,
BIOMD0000000883
,
BIOMD0000000465
,
BIOMD0000000943
,
BIOMD0000000356
,
BIOMD0000000581
,
BIOMD0000000468
Authored
Garapati, P V (2008-12-16)
Reviewed
Bluestone, JA (2009-06-01)
Esensten, J (2009-06-01)
Created
Garapati, P V (2009-01-06)
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