Gads binds CD28

Stable Identifier
R-HSA-389381
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Gads (Grb2-related adaptor protein 2) is essential for CD28 mediated NF-kB activation. This signal is mediated by the binding of Gads to the CD28 YMNM motif. The CD28 cytoplasmic PxxP motif is also required for this association.

Literature References
PubMed ID Title Journal Year
16818765 Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation

Watanabe, R, Harada, Y, Takeda, K, Takahashi, J, Ohnuki, K, Ogawa, S, Ohgai, D, Kaibara, N, Koiwai, O, Tanabe, K, Toma, H, Sugamura, K, Abe, R

J Immunol 2006
Participants
Participant Of
Orthologous Events
Authored
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Created