Reactome | The orphan QRFP receptor can bind neuropeptide QRFP

The orphan QRFP receptor can bind neuropeptide QRFP

Stable Identifier

R-HSA-389424

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
        
        The orphan QRFP receptor can bind neuropeptide QRFP (Homo sapiens)

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The orphan QRFP receptor can bind neuropeptide QRFP

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The orphan QRFP receptor (SP9155) (Lee DK et al, 2001) shares a high sequence homology with the neuropeptide FF receptor. It mediates the activity of neuropeptide QRFP (Jiang Y et al, 2003), which is suspected to have orexigenic activity, via the G alpha-q/11 subunit (Langmead CJ et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
11030716	Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor Herdon, HJ, Hirst, WD, Price, GW, Szekeres, PG, Ratcliffe, SJ, Jones, DN, Chambers, JK, Langmead, CJ	Br J Pharmacol	2000
12714592	Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155 Gustafson, EL, Greene, J, Qiu, P, Yadav, D, Jiang, Y, Murgolo, N, Zhang, FL, Behan, J, Bayne, M, Monsma F, Jr, Zeng, M, Laz, TM, Wang, L, Vassileva, G, Luo, L, Wang, S, Laverty, M	J Biol Chem	2003
11574155	Discovery and mapping of ten novel G protein-coupled receptor genes Evans, JF, Nguyen, T, George, SR, O'Dowd, BF, Lewis, T, Arkhitko, O, Lee, DK, Cheng, R, Lynch, KR, Vanti, WB	Gene	2001