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HCRT(34-66) [extracellular region]
Stable Identifier
R-HSA-389500
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Orexin A, RecName: Full=Orexin; AltName: Full=Hypocretin; Short=Hcrt; Contains: RecName: Full=Orexin-A; AltName: Full=Hypocretin-1; Short=Hcrt1; Contains: RecName: Full=Orexin-B; AltName: Full=Hypocretin-2; Short=Hcrt2; Flags: Precursor;
GN Name=HCRT; Synonyms=OX, PPORX, PPOX;
OS Homo sapiens, OREX_HUMAN, HCRT
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRT(34-66) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRT(34-66) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRT(34-66) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRT(34-66) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRT(34-66) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
HCRT(34-66) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)
HCRT(34-66) [extracellular region] (Homo sapiens)
HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)
HCRT(34-66) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43612 HCRT
Gene Names
HCRT, OX, PPORX, PPOX
Chain
signal peptide:1-33, peptide:34-66, peptide:70-97, propeptide:98-131
Reference Genes
BioGPS Gene:3060 HCRT
COSMIC (genes):HCRT HCRT
CTD Gene:3060 HCRT
dbSNP Gene:3060 HCRT
ENSEMBL:ENSG00000161610 HCRT
HGNC:4847 HCRT
KEGG Gene (Homo sapiens):3060 HCRT
Monarch:3060 HCRT
NCBI Gene:3060 HCRT
OMIM:602358 HCRT
UCSC:O43612 HCRT
Reference Transcript
RefSeq:NM_001524.1 HCRT
Other Identifiers
0001850519
11734517_at
16845073
207642_at
3060
31417_at
3757738
3757739
3757740
3757741
3757742
8015572
A_23_P129989
A_33_P3306624
GE588644
GO:0001659
GO:0003674
GO:0005184
GO:0005575
GO:0005576
GO:0005622
GO:0005737
GO:0005783
GO:0005791
GO:0006810
GO:0006950
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0007205
GO:0007218
GO:0007267
GO:0007268
GO:0007631
GO:0008021
GO:0008150
GO:0008156
GO:0009058
GO:0030054
GO:0030141
GO:0030431
GO:0031410
GO:0031771
GO:0031772
GO:0042592
GO:0042594
GO:0042755
GO:0043226
GO:0043267
GO:0045202
GO:0046928
GO:0048471
GO:0050877
GO:0051928
GO:0051970
GO:0051971
GO:0060079
GO:0098794
GO:0120162
ILMN_1761137
ILMN_2179739
PH_hs_0027899
TC17001527.hg
g4557634_3p_at
Participant Of
input
Orexin 1 receptor can bind orexin-A neuropeptide
hasMember
Ligands of GPCRs that activate Gq/11 [extracellular region]
hasComponent
HCRTR1:HCRT(34-66) [plasma membrane]
Other forms of this molecule
HCRT(70-97) [extracellular region]
Inferred To
hcrt [extracellular region] (Danio rerio)
HCRT(34-66) [extracellular region] (Gallus gallus)
HCRT [extracellular region] (Canis familiaris)
HCRT [extracellular region] (Sus scrofa)
Hcrt [extracellular region] (Mus musculus)
Hcrt [extracellular region] (Rattus norvegicus)
Cross References
RefSeq
NP_001515.1
OpenTargets
ENSG00000161610
GeneCards
O43612
HPA
ENSG00000161610-HCRT
Ensembl
ENST00000293330
,
ENSG00000161610
,
ENSP00000293330
PRO
O43612
Orphanet
16189
PDB
1UVQ
,
1CQ0
,
1WSO
,
1R02
HMDB Protein
HMDBP02340
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21554 CNR1
1
CNR1 [plasma membrane]
(R-HSA-419411)
0.463
2
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