Reactome | BTLA interacts with HVEM

BTLA interacts with HVEM

Stable Identifier

R-HSA-389523

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The B and T lymphocyte attenuator, BTLA, is one of the co-inhibitory receptors of CD28 superfamily along with CTLA-4 and PD-1. BTLA differs from other CD28 members by having an extracellular Ig C-like domain, instead of a V-like one. Herpesvirus entry mediator (HVEM) is the external ligand for BTLA, providing the first example of a functional interaction between a TNFR and an Ig superfamily member. Binding of HVEM to BTLA delivers an inhibitory signal to T cells.

Literature References

PubMed ID	Title	Journal	Year
15568026	B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator Sedy, JR, Ware, CF, Lindsley, RC, Murphy, TL, Gavrieli, M, Hildner, K, Hurchla, MA, Pfeffer, K, Scheu, S, Murphy, KM, Potter, KG	Nat. Immunol.	2005
16932752	Balancing co-stimulation and inhibition with BTLA and HVEM Sedý, JR, Nelson, CA, Murphy, KM	Nat Rev Immunol	2006