Alpha-oxidation of phytanate

Stable Identifier
R-HSA-389599
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Phytanic acid arises through ruminant metabolism of chlorophyll and enters the human diet as a constituent of dairy products (Baxter 1968). It can act as an agonist for PPAR and other nuclear hormone receptors, but its normal role in human physiology, if any, is unclear. It is catabolized via a five-step alpha-oxidation reaction sequence that yields pristanoyl-CoA, which is turn is a substrate for beta-oxidation. These reactions take place in the peroxisomal matrix and their failure is associated with Refsum disease (Wanders et al. 2003).

Literature References
PubMed ID Title Journal Year
12633678 Phytanic acid alpha-oxidation, new insights into an old problem: a review

Wanders, RJ, Jansen, GA, Lloyd, MD

Biochim Biophys Acta 2003
4177872 Absorption of chlorophyll phytol in normal man and in patients with Refsum's disease

Baxter, JH

J Lipid Res 1968
Participants
Participant Of
Event Information
Go Biological Process
Orthologous Events
Authored
Reviewed
Created