2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

Stable Identifier
R-HSA-389611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Peroxisomal HACL1 catalyzes the reaction of 2-hydroxyphytanoyl-CoA to form pristanal and formyl-CoA. The active form of the enzyme is a homotetramer, with one Mg++ and one molecule of thiamin pyrophosphate bound to each monomer (Croes et al. 1997; Foulon et al. 1999).
Literature References
PubMed ID Title Journal Year
9166898 Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids

Casteels, M, Van Veldhoven, PP, Mannaerts, GP, Croes, K

FEBS Lett 1997
10468558 Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids

Waelkens, E, Casteels, M, Van Veldhoven, PP, Mannaerts, GP, Croes, K, Foulon, V, Antonenkov, VD

Proc Natl Acad Sci U S A 1999
Participants
Participates
Catalyst Activity

carbon-carbon lyase activity of HACL1 tetramer [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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