Interaction of SHP-1 or SHP-2 with phospho PD-1

Stable Identifier
R-HSA-389759
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Once phosphorylated, SH2-domain containing tyrosine phosphatases SHP-1 and SHP-2 bind to the ITIM and ITSM motifs of PD-1. The association between SHP-1 and PD-1 appears to be weaker than the interaction of PD-1 with SHP-2.

Literature References
PubMed ID Title Journal Year
18173375 PD-1 and its ligands in tolerance and immunity

Keir, ME, Butte, MJ, Freeman, GJ, Sharpe, AH

Annu Rev Immunol 2008
18759926 Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

Fife, BT, Bluestone, JA

Immunol Rev 2008
Participants
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Orthologous Events
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