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CDC42:GTP, RAC1:GTP [plasma membrane]
Stable Identifier
R-HSA-389778
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Active RAC1/CDC42
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of PAKs by RAC1 and CDC42 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Autophosphorylation of PAK1 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1 and CDC42 activate PAK1 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
Activation of PAKs by RAC1 and CDC42 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
Autophosphorylation of PAK1,2,3 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate IQGAPs (Homo sapiens)
GTP-bound RAC1 and CDC42 bind IQGAPs (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
IQGAP1 binds CLIP1 and microtubules (Homo sapiens)
RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAP1:CLIP1:microtubule [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
IQGAPs bind CALM1 (Homo sapiens)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)
RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
Autophosphorylation of PAK1,2,3 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1 and CDC42 activate PAK1 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1 and CDC42 activate PAK2 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
RAC1 and CDC42 activate PAK3 (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] (Homo sapiens)
CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
Participants
members
CDC42:GTP [plasma membrane]
(Homo sapiens)
RAC1:GTP [plasma membrane]
(Homo sapiens)
Participates
as a component of
RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Homo sapiens)
RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Homo sapiens)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] (Homo sapiens)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Homo sapiens)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Homo sapiens)
as an input of
GTP-bound RAC1 and CDC42 bind IQGAPs (Homo sapiens)
Activation of PAKs by RAC1 and CDC42 (Homo sapiens)
RAC1 and CDC42 activate PAK3 (Homo sapiens)
RAC1 and CDC42 activate PAK1 (Homo sapiens)
RAC1 and CDC42 activate PAK2 (Homo sapiens)
as an output of
Autophosphorylation of PAK1,2,3 (Homo sapiens)
Autophosphorylation of PAK1 (Homo sapiens)
Inferred To
CDC42:GTP [plasma membrane]
(Saccharomyces cerevisiae)
CDC42:GTP [plasma membrane]
(Schizosaccharomyces pombe)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Bos taurus)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Caenorhabditis elegans)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Canis familiaris)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Danio rerio)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Dictyostelium discoideum)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Drosophila melanogaster)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Gallus gallus)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Mus musculus)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Rattus norvegicus)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Sus scrofa)
CDC42:GTP, RAC1:GTP [plasma membrane]
(Xenopus tropicalis)
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