glycine + O2 => glyoxylate + H2O2 + NH4+

Stable Identifier
R-HSA-389821
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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Peroxisomal D-amino-acid oxidase catalyzes the reaction of glycine, water, and O2 to form glyoxylate, H2O2, and NH4+. The active form of the enzyme is a homodimer and has FAD as a cofactor (Kawazoe et al. 2006; Molla et al. 2006).

Literature References
PubMed ID Title Journal Year
16616139 Characterization of human D-amino acid oxidase

Molla, G, Sacchi, S, Bernasconi, M, Pilone, MS, Fukui, K, Polegioni, L

FEBS Lett 2006
17088322 Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring

Kawazoe, T, Tsuge, H, Pilone, MS, Fukui, K

Protein Sci 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
D-amino-acid oxidase activity of DAO dimer [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created