glyoxylate + NADPH + H+ => glycolate + NADP+

Stable Identifier
R-HSA-389826
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxisomal GRHPR catalyzes the reaction of glyoxylate and NADPH + H+ to form glycolate and NADP+. The active form of the enzyme is a monomer (Rumsby and Cregeen 1999); mutations in it are associated with primary hyperoxaluria type II (Cramer et al. 1999).

Literature References
PubMed ID Title Journal Year
10524214 Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase

Rumsby, G, Cregeen, DP

Biochim Biophys Acta 1999
10484776 The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II

Cramer, SD, Ferree, PMPM, Lin, K, Milliner, DS, Holmes, RP

Hum Mol Genet 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glyoxylate reductase (NADP) activity of GRHPR [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created