Conversion of glyoxylate to oxalate

Stable Identifier
R-HSA-389862
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glyoxylate to form oxalate. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

Literature References
PubMed ID Title Journal Year
18215067 Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design

Murray, MS, Holmes, RP, Lowther, WT

Biochemistry 2008
10777549 Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases

Jones, JM, Morrell, JC, Gould, SJ

J Biol Chem 2000
17669354 Purification and characterization of recombinant human liver glycolate oxidase

Vignaud, C, Pietrancosta, N, Williams, EL, Rumsby, G, Lederer, F

Arch Biochem Biophys 2007
10978532 Identification and expression of a cDNA for human glycolate oxidase

Williams, EL, Cregeen, DP, Rumsby, G

Biochim Biophys Acta 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glyoxylate oxidase activity of HAO1 tetramer [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created