(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)

Stable Identifier
R-HSA-389891
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxisomal ACOX3 catalyzes the reaction of (2S)-pristanoyl-CoA and O2 to form trans-2,3-dehydropristanoyl-CoA and H2O2. ACOX3 protein and enzyme activity have been observed in prostate tumors, but are undetectable in normal prostate tissue as well as in liver and kidney (where ACOX2 catalyzes the oxidation of pristanoyl-CoA) (Zha et al. 2005; Vanhooren et al. 1997). The physiological consequences of this differential gene expression are unknown.

Literature References
PubMed ID Title Journal Year
9271077 Evidence for the existence of a pristanoyl-CoA oxidase gene in man

Vanhooren, JC, Marynen, P, Mannaerts, GP, Van Veldhoven, PP

Biochem J 1997
15599942 Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer

Zha, S, Ferdinandusse, S, Hicks, JL, Denis, S, Dunn, TA, Wanders, RJ, Luo, J, De Marzo, AM, Isaacs, WB

Prostate 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
pristanoyl-CoA oxidase activity of ACOX3:FAD [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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