Reactome | p-Y180-ICOS [plasma membrane]

p-Y180-ICOS [plasma membrane]

Stable Identifier

R-HSA-389927

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phosphorylated ICOS

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        p-Y180-ICOS [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        p-Y180-ICOS [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6W8-1 ICOS

Gene Names

ICOS, AILIM

Other Identifiers

11731360_a_at

16889829

210439_PM_at

210439_at

2523879

2523880

2523881

2523885

2523886

2523887

2523889

29851

34607_at

8047702

GE79870

GO:0002376

GO:0002517

GO:0005515

GO:0005576

GO:0005886

GO:0006955

GO:0007155

GO:0016020

GO:0031295

GO:0048856

GO:0098609

HMNXSV003006044

ILMN_1669927

PH_hs_0003666

TC02001202.hg

g5360718_3p_at

Participates

as an input of

PI3K binds ICOS (Homo sapiens)

as a component of

ICOS:PI3K [plasma membrane] (Homo sapiens)

Other forms of this molecule

ICOS-1 [plasma membrane]

Inferred To

phospho-Icos [plasma membrane] (Mus musculus)

phospho-Icos [plasma membrane] (Rattus norvegicus)

phospho-p-Y180-ICOS [plasma membrane] (Gallus gallus)

phospho-p-Y180-ICOS [plasma membrane] (Sus scrofa)

phospho-ICOS [plasma membrane] (Bos taurus)

phospho-ICOS [plasma membrane] (Canis familiaris)

phospho-icos [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 180

Coordinate

180

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_036224.1

Guide to Pharmacology - Targets

2939

OpenTargets

ENSG00000163600

GeneCards

Q9Y6W8

HPA

ENSG00000163600-ICOS

Ensembl

ENSG00000163600, ENSP00000319476, ENSP00000415951, ENST00000435193, ENST00000316386

PRO

Q9Y6W8

Pharos - Targets

Q9Y6W8

Orphanet

16238

PDB

7JOO, 6X4G

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75144 ICOSLG	1	ICOSLG [plasma membrane] (R-HSA-197910)	0.733	8
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.623	5
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267)	0.499	5