Reactome | SHP-1 and SHP-2 bind pBTLA

SHP-1 and SHP-2 bind pBTLA

Stable Identifier

R-HSA-389941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The cytoplasmic tail of BTLA contains three tyrosine residues that are conserved in most organisms. The tyrosine residues Y257 and Y282 are both present in ITIM motif sequences. These tyrosine residues are phosphorylated after BTLA cross-linking, and both ITIM motifs recruit the tyrosine phosphatases SHP1 and SHP2. The targets of SHP1 and SHP2 recruited to BTLA are not known, although it is possible that they also have a role in dephosphorylating signaling intermediates downstream of antigen receptors in lymphocytes or in specifically targeting the PI3K-AKT pathway.

Literature References

PubMed ID	Title	Journal	Year
12796776	BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 Hurchla, MA, Fallarino, F, Zimmerman, N, Sedý, JR, Gavrieli, M, Loftin, SK, Zang, X, Murphy, KM, Sim, J, Murphy, TL, Russell, JH, Allison, JP, Yang, J, Watanabe, N	Nat Immunol	2003
16932752	Balancing co-stimulation and inhibition with BTLA and HVEM Sedý, JR, Nelson, CA, Murphy, KM	Nat Rev Immunol	2006