Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC

Stable Identifier
R-HSA-389954
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Group II chaperonins enclose substrate proteins following substrate binding through the formation of a "built- in" lid over the central cavity. Upon ATP binding, lid formation is triggered by the transition state of ATP hydrolysis (Meyer, et al., 2003). In the case of CCT-mediated tubulin folding, one or more rounds of ATP hydrolysis are likely required before the association of non-exchangeable GTP with chaperonin-bound alpha tubulin.

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