Prefoldin mediated transfer of substrate to CCT/TriC

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Metabolism of proteins (Homo sapiens)

• • Protein folding (Homo sapiens)
    • Chaperonin-mediated protein folding (Homo sapiens)
      • Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
        • Prefoldin mediated transfer of substrate to CCT/TriC (Homo sapiens)

Summation

Unfolded actins and tubulins bound to prefoldin are transferred to CCT via a docking mechanism (McCormack and Willison, 2001).

Literature References

PubMed ID	Title	Journal	Year

11580269

Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT

J Struct Biol

2001

Participants

events

• Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)
• unfolded actin/tubulin associates with prefoldin (Homo sapiens)

Participant Of

hasEvent

• Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Orthologous Events

• Prefoldin mediated transfer of substrate to CCT/TriC (Bos taurus)