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SUMO1-K53-DDX5 [nucleoplasm]
Stable Identifier
R-HSA-3900041
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Probable ATP-dependent RNA helicase DDX5 ecNumber3.6.4.13/ecNumber, DDX5_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of DDX5 with SUMO1 (Homo sapiens)
SUMO1:DDX5 [nucleoplasm] (Homo sapiens)
SUMO1-K53-DDX5 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
19995069
Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential
Mooney, SM
,
Grande, JP
,
Salisbury, JL
,
Janknecht, R
Biochemistry
2010
External Reference Information
External Reference
UniProt:P17844 DDX5
Gene Names
DDX5, G17P1, HELR, HLR1
Chain
chain:1-614
Reference Genes
BioGPS Gene:1655 DDX5
COSMIC (genes):DDX5 DDX5
CTD Gene:1655 DDX5
dbSNP Gene:1655 DDX5
ENSEMBL:ENSG00000108654 DDX5
HGNC:2746 DDX5
KEGG Gene (Homo sapiens):1655 DDX5
Monarch:1655 DDX5
NCBI Gene:1655 DDX5
OMIM:180630 DDX5
UCSC:P17844 DDX5
Reference Transcript
RefSeq:NM_001320595.1 DDX5
RefSeq:NM_004396.4 DDX5
RefSeq:NM_001320596.1 DDX5
Other Identifiers
11733798_at
11745795_s_at
11750815_s_at
11757332_x_at
1655
16847820
18671562
18671563
18671564
18671566
18671567
18671568
18671569
18671570
18671571
18671572
18671573
18671574
18671575
18671576
18671577
18671578
200033_at
200033_PM_at
20043
225886_at
34647_at
3766891
3766892
3766894
3766895
3766896
3766899
3766900
3766912
3766914
3766916
3766918
3766920
3766922
3766924
3766926
3766927
3766929
3766936
3766937
3766938
3FE2
4A4D
5868
7892829
7892857
7893407
7893516
7893530
7894055
7894666
7894685
7894896
7895517
7896169
7896185
7896247
7896427
7896683
8017634
A_23_P15511
AAB84094
AAH16027
AAP35589
AB451257
AC009994
AF015812
AJ010931
AK297192
BAG59680
BAG70071
BC016027
BT006943
CAA09408
CAA33751
CAA36324
CAB005868
CCDS11659
CH471109
DDX5
DDX5-201
DDX5-202
EAW94202
EAW94203
ENSG00000108654
ENSP00000225792
ENSP00000403085
ENST00000225792
ENST00000225792.9
ENST00000450599
ENST00000450599.6
EntrezGene:1655
EntrezGene:DDX5
g13514826_3p_at
GE81390
GO:0000122
GO:0000166
GO:0000380
GO:0000381
GO:0000398
GO:0000956
GO:0001837
GO:0003674
GO:0003676
GO:0003723
GO:0003724
GO:0003729
GO:0003730
GO:0004386
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005681
GO:0005730
GO:0005737
GO:0006357
GO:0006397
GO:0006950
GO:0007165
GO:0008134
GO:0008150
GO:0008219
GO:0008380
GO:0009056
GO:0009058
GO:0009299
GO:0016020
GO:0016787
GO:0016887
GO:0019899
GO:0030154
GO:0030509
GO:0030520
GO:0030521
GO:0032991
GO:0034641
GO:0034655
GO:0035500
GO:0036002
GO:0043021
GO:0043167
GO:0043226
GO:0043517
GO:0044403
GO:0045069
GO:0045445
GO:0045667
GO:0046332
GO:0048306
GO:0048511
GO:0048856
GO:0050681
GO:0060765
GO:0061614
GO:0070062
GO:0070412
GO:0070878
GO:0071013
GO:0072332
GO:1903800
GO:1990841
GO:1990904
GO:2001014
HGNC:2746
HPA020043
Hs.279806.0.S1_3p_at
Hs.279806.0.S1_3p_x_at
ILMN_1805344
IPR000629
IPR001650
IPR011545
IPR012587
IPR014001
IPR014014
IPR027417
J3KRX8
J3KRZ1
J3KTA4
J3KTQ4
J3QKN9
J3QLG9
J3QR02
J3QR62
J3QRN5
J3QRQ7
J3QS79
J3QS97
MIM:180630
NM_001320595
NM_001320596
NM_004396
NP_001307524
NP_001307525
NP_004387
PF00270
PF00271
PF08061
PH_hs_0014403
SM00487
SM00490
SM01414
TC17001800.hg
UPI000003B456
UPI00017A73EC
X15729
X15729_s_at
X52104
X6RLV5
Participant Of
hasComponent
SUMO1:DDX5 [nucleoplasm]
Other forms of this molecule
DDX5 [nucleoplasm]
SUMO2-K53-DDX5 [nucleoplasm]
Inferred To
DBP2 [nucleoplasm] (Saccharomyces cerevisiae)
DDX5 [nucleoplasm] (Bos taurus)
DDX5 [nucleoplasm] (Canis familiaris)
dbp2 [nucleoplasm] (Schizosaccharomyces pombe)
Homologues of SUMO1-K53-DDX5 [nucleoplasm] (Dictyostelium discoideum)
Homologues of SUMO1-K53-DDX5 [nucleoplasm] (Plasmodium falciparum)
ddx5 [nucleoplasm] (Danio rerio)
ddx5 [nucleoplasm] (Dictyostelium discoideum)
ddx5 [nucleoplasm] (Xenopus tropicalis)
Ddx5 [nucleoplasm] (Mus musculus)
Ddx5 [nucleoplasm] (Rattus norvegicus)
SUMO1-K53-DDX5 [nucleoplasm] (Dictyostelium discoideum)
SUMO1-K53-DDX5 [nucleoplasm] (Gallus gallus)
SUMO1-K53-DDX5 [nucleoplasm] (Plasmodium falciparum)
SUMO1-K53-DDX5 [nucleoplasm] (Sus scrofa)
ddx17 [nucleoplasm] (Dictyostelium discoideum)
Modified Residues
Name
Inter-chain Crosslink via sumoylated lysine at 53 and 97
Coordinate
53
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001307524.1
,
NP_001307525.1
,
NP_004387.1
Target Pathogen
5b354852be737e166372e76c
OpenTargets
ENSG00000108654
GeneCards
P17844
HPA
ENSG00000108654-DDX5
Ensembl
ENST00000450599
,
ENSG00000108654
,
ENSP00000403085
,
ENSP00000225792
,
ENST00000225792
PRO
P17844
HMDB Protein
HMDBP11690
PDB
3FE2
,
4A4D
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRR4 DROSHA
1
DROSHA [nucleoplasm]
(R-HSA-1482510)
0.737
6
UniProt:P27958-PRO_0000037577
0.733
12
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.656
6
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.643
4
UniProt:P24928 POLR2A
7
p-S5,S7-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S2,S7-POLR2A [nucleoplasm]
(R-HSA-6814543)
p-S5-POLR2A [nucleoplasm]
(R-HSA-77100)
Ub,p-S2,S5-POLR2A [nucleoplasm]
(R-HSA-6781855)
POLR2A [nucleoplasm]
(R-HSA-63502)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
p-S2,S5-POLR2A [nucleoplasm]
(R-HSA-113420)
0.641
3
UniProt:Q15797 SMAD1
4
SMAD1 [cytosol]
(R-HSA-201468)
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
0.612
4
UniProt:Q09472 EP300
5
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
SUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.61
4
UniProt:O94916 NFAT5
0.591
4
UniProt:Q13547 HDAC1
2
SUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
HDAC1 [nucleoplasm]
(R-HSA-205021)
0.576
4
UniProt:Q99717 SMAD5
3
p-S463,S465-SMAD5 [nucleoplasm]
(R-HSA-201432)
SMAD5 [cytosol]
(R-HSA-201431)
p-S463,S465-SMAD5 [cytosol]
(R-HSA-201473)
0.558
3
UniProt:Q92841 DDX17
2
SUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
DDX17 [nucleoplasm]
(R-HSA-3900090)
0.547
3
UniProt:P04637-1 TP53
0.544
2
UniProt:P04637-7 TP53
0.544
2
UniProt:P22087 FBL
1
FBL [nucleoplasm]
(R-HSA-6790638)
0.543
6
UniProt:Q92841-4 DDX17
0.527
2
UniProt:P45481 Crebbp
4
Crebbp [nucleoplasm]
(R-MMU-556795)
Crebbp [nucleoplasm]
(R-MMU-193545)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
Sumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.524
3
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.524
3
UniProt:P51858 HDGF
1
HDGF [nucleoplasm]
(R-HSA-535593)
0.512
4
UniProt:Q9H871 RMD5A
0.508
2
UniProt:Q7L5Y9 MAEA
0.508
2
UniProt:Q1K9H5 Q1K9H5
0.508
2
UniProt:P62699 YPEL5
3
YPEL5 [extracellular region]
(R-HSA-6806435)
YPEL5 [ficolin-1-rich granule lumen]
(R-HSA-6800954)
YPEL5 [tertiary granule lumen]
(R-HSA-6800422)
0.508
2
UniProt:Q96S59 RANBP9
1
RANBP9 [cytosol]
(R-HSA-374586)
0.508
2
UniProt:Q8AZK7 EBNA5
0.499
2
UniProt:P84022 SMAD3
21
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [cytosol]
(R-HSA-170855)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
0.499
2
UniProt:P29991-PRO_0000037946
0.488
2
UniProt:P10085 Myod1
2
Myod1 [nucleoplasm]
(R-MMU-445441)
MYOD1_MOUSE [nucleoplasm]
(R-MMU-448840)
0.462
3
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