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monoSUMO1-K53-DDX5 [nucleoplasm]
Stable Identifier
R-HSA-3900041
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Probable ATP-dependent RNA helicase DDX5 ecNumber3.6.4.13/ecNumber, DDX5_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of DDX5 with SUMO1 (Homo sapiens)
monoSUMO1-K53-DDX5 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
19995069
Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential
Salisbury, JL
,
Grande, JP
,
Janknecht, R
,
Mooney, SM
Biochemistry
2010
External Reference Information
External Reference
UniProt:P17844 DDX5
Gene Names
DDX5, G17P1, HELR, HLR1
Chain
chain:1-614
Reference Genes
BioGPS Gene:1655 DDX5
COSMIC (genes):DDX5 DDX5
CTD Gene:1655 DDX5
dbSNP Gene:1655 DDX5
ENSEMBL:ENSG00000108654 DDX5
HGNC:2746 DDX5
KEGG Gene (Homo sapiens):1655 DDX5
Monarch:1655 DDX5
NCBI Gene:1655 DDX5
OMIM:180630 DDX5
UCSC:P17844 DDX5
Reference Transcript
RefSeq:NM_001320595.1 DDX5
RefSeq:NM_001320596.1 DDX5
RefSeq:NM_004396.4 DDX5
Other Identifiers
0006510446
11733798_at
11745795_s_at
11750815_s_at
11757332_x_at
1655
16847820
18671562
18671563
18671564
18671566
18671567
18671568
18671569
18671570
18671571
18671572
18671573
18671574
18671575
18671576
18671577
18671578
200033_PM_at
200033_at
225886_at
34647_at
3766891
3766892
3766894
3766895
3766896
3766899
3766900
3766912
3766914
3766916
3766918
3766920
3766922
3766924
3766926
3766927
3766929
3766936
3766937
3766938
3766939
3766940
7892829
7892857
7893407
7893516
7893530
7894055
7894666
7894685
7894896
7895517
7896169
7896185
7896247
7896427
7896683
8017634
A_23_P15511
GE81390
GO:0000122
GO:0000166
GO:0000380
GO:0000381
GO:0000398
GO:0000956
GO:0001837
GO:0003674
GO:0003676
GO:0003723
GO:0003724
GO:0003729
GO:0003730
GO:0004386
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005681
GO:0005730
GO:0005737
GO:0005829
GO:0006357
GO:0006397
GO:0006950
GO:0007165
GO:0008134
GO:0008150
GO:0008219
GO:0008380
GO:0009056
GO:0009058
GO:0009299
GO:0016020
GO:0016787
GO:0016887
GO:0019899
GO:0030154
GO:0030509
GO:0030520
GO:0030521
GO:0032991
GO:0034641
GO:0034655
GO:0035500
GO:0036002
GO:0043021
GO:0043167
GO:0043226
GO:0043517
GO:0044403
GO:0045069
GO:0045445
GO:0045667
GO:0046332
GO:0048306
GO:0048511
GO:0048856
GO:0050681
GO:0060765
GO:0061614
GO:0070062
GO:0070412
GO:0070878
GO:0071013
GO:0072332
GO:1903800
GO:1990841
GO:1990904
GO:2001014
HMNXSV003017450
HMNXSV003018058
Hs.279806.0.S1_3p_at
Hs.279806.0.S1_3p_x_at
ILMN_1805344
PH_hs_0014403
TC17001800.hg
X15729_s_at
g13514826_3p_at
Participates
as an output of
SUMOylation of DDX5 with SUMO1 (Homo sapiens)
Other forms of this molecule
DDX5 [nucleoplasm]
DDX5 [cytosol]
polySUMO2-K53-DDX5 [nucleoplasm]
Inferred To
DBP2 [nucleoplasm]
(Saccharomyces cerevisiae)
DDX5 [nucleoplasm]
(Gallus gallus)
dbp2 [nucleoplasm]
(Schizosaccharomyces pombe)
ddx5 [nucleoplasm]
(Danio rerio)
Homologues of monoSUMO1-K53-DDX5 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of monoSUMO1-K53-DDX5 [nucleoplasm]
(Plasmodium falciparum)
Ddx5 [nucleoplasm]
(Mus musculus)
Ddx5 [nucleoplasm]
(Rattus norvegicus)
ddx17 [nucleoplasm]
(Dictyostelium discoideum)
monoSUMO1-K53-DDX5 [nucleoplasm]
(Dictyostelium discoideum)
monoSUMO1-K53-DDX5 [nucleoplasm]
(Plasmodium falciparum)
monoSUMO1-K53-DDX5 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 53
Coordinate
53
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001307524.1
,
NP_004387.1
,
NP_001307525.1
OpenTargets
ENSG00000108654
GeneCards
P17844
HPA
ENSG00000108654-DDX5
Ensembl
ENSG00000108654
,
ENST00000225792
,
ENSP00000225792
,
ENST00000450599
,
ENSP00000403085
PRO
P17844
Pharos - Targets
P17844
GlyGen
P17844
PDB
4A4D
,
3FE2
HMDB Protein
HMDBP11690
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRR4 DROSHA
1
DROSHA [nucleoplasm]
(R-HSA-1482510)
0.737
6
UniProt:P27958-PRO_0000037577
0.733
12
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.656
6
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.643
4
UniProt:P24928 POLR2A
7
p-S2,S7-POLR2A [nucleoplasm]
(R-HSA-6814543)
p-S5,S7-POLR2A [nucleoplasm]
(R-HSA-6810226)
Ub,p-S2,S5-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
p-S2,S5-POLR2A [nucleoplasm]
(R-HSA-113420)
POLR2A [nucleoplasm]
(R-HSA-63502)
p-S5-POLR2A [nucleoplasm]
(R-HSA-77100)
0.641
3
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
SMAD1 [cytosol]
(R-HSA-201468)
0.612
4
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.61
4
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.576
4
UniProt:O94916 NFAT5
0.563
4
UniProt:Q99717 SMAD5
3
p-S463,S465-SMAD5 [nucleoplasm]
(R-HSA-201432)
p-S463,S465-SMAD5 [cytosol]
(R-HSA-201473)
SMAD5 [cytosol]
(R-HSA-201431)
0.558
3
UniProt:Q13148 TADBP
0.556
3
UniProt:Q92841 DDX17
2
DDX17 [nucleoplasm]
(R-HSA-3900090)
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
0.547
3
UniProt:P04637-1 TP53
0.544
2
UniProt:P04637-7 TP53
0.544
2
UniProt:P22087 FBL
1
FBL [nucleoplasm]
(R-HSA-6790638)
0.543
6
UniProt:Q96SB4 SRPK1
1
SRPK1 [cytosol]
(R-HSA-9729349)
0.527
2
UniProt:Q92841-4 DDX17
0.527
2
UniProt:P45481 Crebbp
4
Crebbp [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.524
3
UniProt:P51858 HDGF
1
HDGF [nucleoplasm]
(R-HSA-535593)
0.512
4
UniProt:Q9H871 RMD5A
0.508
2
UniProt:Q7L5Y9 MAEA
0.508
2
UniProt:Q1K9H5 Q1K9H5
0.508
2
UniProt:P62699 YPEL5
3
YPEL5 [ficolin-1-rich granule lumen]
(R-HSA-6800954)
YPEL5 [tertiary granule lumen]
(R-HSA-6800422)
YPEL5 [extracellular region]
(R-HSA-6806435)
0.508
2
UniProt:Q96S59 RANBP9
1
RANBP9 [cytosol]
(R-HSA-374586)
0.508
2
UniProt:Q8AZK7 EBNA5
0.499
2
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [cytosol]
(R-HSA-170855)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
0.499
2
UniProt:P29991-PRO_0000037946
0.488
2
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.471
3
UniProt:P10085 Myod1
2
MYOD1_MOUSE [nucleoplasm]
(R-MMU-448840)
Myod1 [nucleoplasm]
(R-MMU-445441)
0.462
3
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