Reactome | DDX5 [nucleoplasm]

DDX5 [nucleoplasm]

Stable Identifier

R-HSA-3900136

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable ATP-dependent RNA helicase DDX5 ecNumber3.6.4.13/ecNumber, DDX5_HUMAN, p68

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Estrogen-dependent gene expression (Homo sapiens)
      - CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
      - DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
      - Estrogen-responsive TFF1 gene expression (Homo sapiens)
        
        ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
      - Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
      - PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
      - TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
        
        DDX5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17844 DDX5

Gene Names

DDX5, G17P1, HELR, HLR1

Chain

chain:1-614

Reference Genes

BioGPS Gene:1655 DDX5

COSMIC (genes):DDX5 DDX5

CTD Gene:1655 DDX5

dbSNP Gene:1655 DDX5

ENSEMBL:ENSG00000108654 DDX5

ENSEMBL:ENSG00000108654.16 DDX5

HGNC:2746 DDX5

KEGG Gene (Homo sapiens):1655 DDX5

Monarch:1655 DDX5

NCBI Gene:1655 DDX5

OMIM:180630 DDX5

UCSC:P17844 DDX5

Reference Transcript

Other Identifiers

11733798_at

11745795_s_at

11750815_s_at

11757332_x_at

1655

16847820

18671562

18671563

18671564

18671566

18671567

18671568

18671569

18671570

18671571

18671572

18671573

18671574

18671575

18671576

18671577

18671578

200033_PM_at

200033_at

225886_PM_at

225886_at

34647_at

3766891

3766892

3766894

3766895

3766896

3766899

3766900

3766912

3766914

3766916

3766918

3766920

3766922

3766924

3766926

3766927

3766929

3766936

3766937

3766938

3766939

3766940

3766941

3766942

3766943

3766944

3766945

3766946

7892829

7892857

7893407

7893516

7893530

7894055

7894666

7894685

7894896

7895517

7896169

7896185

7896247

7896427

7896683

8017634

A_23_P15511

A_33_P3299942

GE81390

GO:0000122

GO:0000166

GO:0000380

GO:0000381

GO:0000398

GO:0000956

GO:0001837

GO:0003676

GO:0003723

GO:0003724

GO:0003730

GO:0003824

GO:0004386

GO:0005515

GO:0005516

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006397

GO:0008380

GO:0009299

GO:0012501

GO:0016020

GO:0016071

GO:0016607

GO:0016787

GO:0016887

GO:0019899

GO:0023052

GO:0030154

GO:0030509

GO:0030520

GO:0030521

GO:0031047

GO:0031053

GO:0035500

GO:0036002

GO:0043021

GO:0043226

GO:0043517

GO:0045069

GO:0045445

GO:0045667

GO:0046332

GO:0048306

GO:0048511

GO:0048856

GO:0050681

GO:0060765

GO:0061614

GO:0070062

GO:0070412

GO:0070878

GO:0071013

GO:0072332

GO:0140098

GO:0140657

GO:1990841

GO:1990904

GO:2001014

HMNXSV003005434

HMNXSV003017450

HMNXSV003018058

Hs.279806.0.S1_3p_at

Hs.279806.0.S1_3p_x_at

ILMN_1805344

PH_hs_0014403

TC17001800.hg

X15729_s_at

g13514826_3p_at

p33907

Participates

as a component of

as an input of

as an output of

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)

Other forms of this molecule

DDX5 [cytosol]

polySUMO2-K53-DDX5 [nucleoplasm]

monoSUMO1-K53-DDX5 [nucleoplasm]

Inferred To

wu:fa56a07 [nucleoplasm] (Danio rerio)

DDX5 [nucleoplasm] (Bos taurus)

DDX5 [nucleoplasm] (Canis familiaris)

DDX5 [nucleoplasm] (Dictyostelium discoideum)

DDX5 [nucleoplasm] (Gallus gallus)

DDX5 [nucleoplasm] (Mus musculus)

DDX5 [nucleoplasm] (Plasmodium falciparum)

DDX5 [nucleoplasm] (Saccharomyces cerevisiae)

DDX5 [nucleoplasm] (Schizosaccharomyces pombe)

DDX5 [nucleoplasm] (Sus scrofa)

ddx-17 [nucleoplasm] (Caenorhabditis elegans)

DmRH5 [nucleoplasm] (Drosophila melanogaster)

ddx5 [nucleoplasm] (Xenopus tropicalis)

Ddx5 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001307524.1, NP_001307525.1, NP_004387.1

OpenTargets

ENSG00000108654

IntEnz

3.6.4.13

GeneCards

P17844

HPA

ENSG00000108654-DDX5

Ensembl

ENST00000225792, ENSP00000504794, ENSP00000403085, ENSP00000464337, ENSG00000108654, ENST00000577922, ENST00000585111, ENST00000676785, ENSP00000225792, ENST00000450599, ENSP00000463168

PRO

P17844

Pharos - Targets

P17844

HMDB Protein

HMDBP11690

PDB

3FE2, 4A4D

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRR4 DROSHA	1	DROSHA [nucleoplasm] (R-HSA-1482510)	0.737	6
UniProt:P27958-PRO_0000037577			0.733	12
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.656	6
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.643	4
UniProt:P24928 POLR2A	7	p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) POLR2A [nucleoplasm] (R-HSA-63502) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100)	0.641	3
UniProt:Q15797 SMAD1	4	Ub-SMAD1 [cytosol] (R-HSA-6782768) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) SMAD1 [cytosol] (R-HSA-201468)	0.612	4
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.61	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.576	4
UniProt:O94916 NFAT5			0.563	4
UniProt:Q99717 SMAD5	3	p-S463,S465-SMAD5 [nucleoplasm] (R-HSA-201432) p-S463,S465-SMAD5 [cytosol] (R-HSA-201473) SMAD5 [cytosol] (R-HSA-201431)	0.558	3
UniProt:Q13148 TADBP			0.556	3
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.547	3
UniProt:P04637-1 TP53			0.544	2
UniProt:P04637-7 TP53			0.544	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.543	6
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.527	2
UniProt:Q92841-4 DDX17			0.527	2
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.524	3
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.512	4
UniProt:Q9H871 RMD5A			0.508	2
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.508	2
UniProt:Q7L5Y9 MAEA			0.508	2
UniProt:Q1K9H5 Q1K9H5			0.508	2
UniProt:P62699 YPEL5	3	YPEL5 [tertiary granule lumen] (R-HSA-6800422) YPEL5 [extracellular region] (R-HSA-6806435) YPEL5 [ficolin-1-rich granule lumen] (R-HSA-6800954)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.499	2
UniProt:P29991-PRO_0000037946			0.488	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.471	3
UniProt:P10085 Myod1	2	MYOD1_MOUSE [nucleoplasm] (R-MMU-448840) Myod1 [nucleoplasm] (R-MMU-445441)	0.462	3

Cite Us!