Dephosphorylation of AKT by PP2A

Stable Identifier
R-HSA-390329
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dephosphorylation of AKT by PP2A
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
When CTLA4 is engaged by B7 molecules, PP2A disassociates from CTLA4 in a phosphorylation dependent manner. Released PP2A acts downstream of early TCR and CD28 signaling, by inhibition of the PKB/Akt pathway.
Literature References
PubMed ID Title Journal Year
19405949 Structure-Function analysis of the CTLA-4 interaction with PP2A

Madrenas, J, Chau, TA, Teft, WA

BMC Immunol 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidate phosphatase activity of PP2A [cytosol]

Physical Entity
PP2A [cytosol] (Homo sapiens)
Activity
phosphatidate phosphatase activity (GO:0008195)
Orthologous Events
Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Drosophila melanogaster)
Dephosphorylation of AKT by PP2A (Mus musculus)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)
Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-26)
Cite Us!