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TCP1 [cytosol]
Stable Identifier
R-HSA-390448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
T-complex protein 1 subunit alpha (TCP-1-alpha)
Locations in the PathwayBrowser for interactor UniProt:Q13882 PTK6
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of TCP1 (Homo sapiens)
TCP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17987 TCP1
Gene Names
TCP1, CCT1, CCTA
Chain
chain:1-556
Reference Genes
BioGPS Gene:6950 TCP1
COSMIC (genes):TCP1 TCP1
CTD Gene:6950 TCP1
dbSNP Gene:6950 TCP1
ENSEMBL:ENSG00000120438 TCP1
HGNC:11655 TCP1
KEGG Gene (Homo sapiens):6950 TCP1
Monarch:6950 TCP1
NCBI Gene:6950 TCP1
OMIM:186980 TCP1
UCSC:P17987 TCP1
Reference Transcript
RefSeq:NM_030752.2 TCP1
Other Identifiers
0001090129
11722018_a_at
11741319_a_at
17025297
208778_s_at
222010_at
222011_s_at
2982382
2982383
2982384
2982385
2982387
2982389
2982393
2982395
2982400
2982402
2982405
2982409
2982411
2982413
2982417
2982418
2999263
2999271
3407336
3407359
3407360
3407362
3407363
3407365
3407367
34791_at
6950
8130567
A_23_P122782
A_33_P3349947
GE61593
GE86458
GO:0000003
GO:0000166
GO:0000242
GO:0000792
GO:0001669
GO:0002199
GO:0003674
GO:0003723
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005694
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0006259
GO:0006457
GO:0006810
GO:0007021
GO:0007165
GO:0007339
GO:0008150
GO:0008219
GO:0009058
GO:0015031
GO:0016887
GO:0019899
GO:0022607
GO:0031410
GO:0031625
GO:0032212
GO:0032991
GO:0034641
GO:0035722
GO:0042592
GO:0043167
GO:0043226
GO:0044053
GO:0044183
GO:0044297
GO:0044403
GO:0050821
GO:0051082
GO:0051276
GO:0051973
GO:0065003
GO:0070062
GO:0090666
GO:1901998
GO:1904851
GO:1904871
GO:1904874
GO:2000109
HMNXSV003013792
Hs.278544.2.A1_3p_s_at
ILMN_1660661
ILMN_1776347
ILMN_2313434
PH_hs_0000453
TC06002277.hg
X52882_at
g12653758_3p_s_at
Participates
as a component of
BBS/CCT complex [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
as an output of
Expression of TCP1 (Homo sapiens)
Inferred To
CCT1 [cytosol]
(Drosophila melanogaster)
Tcp1 [cytosol]
(Mus musculus)
Tcp1 [cytosol]
(Rattus norvegicus)
cct1 [cytosol]
(Schizosaccharomyces pombe)
cct-1 [cytosol]
(Caenorhabditis elegans)
tcp1 [cytosol]
(Danio rerio)
tcp1 [cytosol]
(Dictyostelium discoideum)
TCP1 [cytosol]
(Canis familiaris)
TCP1 [cytosol]
(Gallus gallus)
TCP1 [cytosol]
(Plasmodium falciparum)
TCP1 [cytosol]
(Saccharomyces cerevisiae)
TCP1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_110379.2
OpenTargets
ENSG00000120438
GeneCards
P17987
HPA
ENSG00000120438-TCP1
Ensembl
ENSP00000317334
,
ENST00000321394
,
ENSG00000120438
PRO
P17987
Pharos - Targets
P17987
GlyGen
P17987
PDB
6QB8
,
6NRB
,
6NR8
,
6NRA
,
7LUM
,
6NRC
,
6NR9
,
7LUP
,
6NRD
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.725
4
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
0.69
4
UniProt:P78371 CCT2
3
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [cytosol]
(R-HSA-390464)
0.688
3
UniProt:P83110-2 HTRA3
0.644
7
UniProt:P78380 OLR1
3
OLR1 [tertiary granule membrane]
(R-HSA-6800883)
OLR1 [plasma membrane]
(R-HSA-203139)
OLR1 [specific granule membrane]
(R-HSA-6799518)
0.644
5
UniProt:P62714 PPP2CB
4
MeL-PPP2CB [nucleoplasm]
(R-HSA-8857799)
p-Y307-PPP2CB [cytosol]
(R-HSA-8857935)
PPP2CB [nucleoplasm]
(R-HSA-165991)
PPP2CB [cytosol]
(R-HSA-165987)
0.643
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.643
4
UniProt:P60510 PPP4C
1
PPP4C [nucleoplasm]
(R-HSA-5687750)
0.643
3
UniProt:Q13033 STRN3
0.643
3
UniProt:P83110-1 HTRA3
0.632
6
UniProt:P83105 HTRA4
0.621
7
UniProt:P61962 DCAF7
2
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
DCAF7 [nucleoplasm]
(R-HSA-8863312)
0.615
3
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.597
4
UniProt:Q99759 MAP3K3
1
MAP3K3 [cytosol]
(R-HSA-507725)
0.564
2
UniProt:P50990 CCT8
5
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [cytosol]
(R-HSA-390449)
0.564
2
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.564
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.564
2
UniProt:O43439 MTG8R
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q9ULD4-2 Q9ULD42
0.556
3
UniProt:Q9Y2Y0 ARL2BP
2
ARL2BP [cytosol]
(R-HSA-5215982)
ARL2BP [mitochondrial matrix]
(R-HSA-5250220)
0.556
3
UniProt:P83110 HTRA3
0.537
5
UniProt:Q15120 PDK3
1
PDK3(?-406) [mitochondrial matrix]
(R-HSA-203940)
0.527
2
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
2
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.527
2
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.527
2
UniProt:P23258 TUBG1
1
TUBG1 [cytosol]
(R-HSA-379269)
0.527
2
UniProt:Q71U36 TUBA1A
9
AcK-TUBA1A [cytosol]
(R-HSA-5618312)
Ac K40 TUBA1A [axonemal microtubule]
(R-HSA-5624852)
TUBA1A [cytosol]
(R-HSA-191689)
TUBA1A [axonemal microtubule]
(R-HSA-5610433)
TUBA1A(1-450) [cytosol]
(R-HSA-8955577)
Polyglutamyl-TUBA1A [cytosol]
(R-HSA-8867408)
L-isoglutamyl polyglycyl-TUBA1A [cytosol]
(R-HSA-8867428)
TUBA1A unfolded [cytosol]
(R-HSA-392767)
TUBA1A folding intermediate [cytosol]
(R-HSA-392805)
0.527
4
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
0.527
2
UniProt:Q9BXA6 TSSK6
0.527
2
UniProt:P78318 IGBP1
0.527
2
UniProt:Q9Y2T4 2ABG
0.527
2
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
PTK6 [cytosol]
(R-HSA-8848000)
0.527
3
UniProt:P52333 JAK3
6
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
JAK3 [endosome]
(R-HSA-8983184)
p-JAK3 [cytosol]
(R-HSA-8982856)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
JAK3 [cytosol]
(R-HSA-451893)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
9
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.527
2
UniProt:Q8NBT0 POC1A
0.483
2
UniProt:Q00005 2ABB
0.462
3
UniProt:Q8IWZ6 BBS7
1
BBS7 [cytosol]
(R-HSA-5617632)
0.462
2
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