Reactome | TCP1 [cytosol]

TCP1 [cytosol]

Stable Identifier

R-HSA-390448

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit alpha (TCP-1-alpha)

Locations in the PathwayBrowser for interactor UniProt:Q13882 PTK6

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of TCP1 (Homo sapiens)
        
        TCP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17987 TCP1

Gene Names

TCP1, CCT1, CCTA

Chain

chain:1-556

Reference Genes

BioGPS Gene:6950 TCP1

COSMIC (genes):TCP1 TCP1

CTD Gene:6950 TCP1

dbSNP Gene:6950 TCP1

ENSEMBL:ENSG00000120438 TCP1

HGNC:11655 TCP1

KEGG Gene (Homo sapiens):6950 TCP1

Monarch:6950 TCP1

NCBI Gene:6950 TCP1

OMIM:186980 TCP1

UCSC:P17987 TCP1

Reference Transcript

RefSeq:NM_030752.2 TCP1

Other Identifiers

0001090129

11722018_a_at

11741319_a_at

17025297

208778_s_at

222010_at

222011_s_at

2982382

2982383

2982384

2982385

2982387

2982389

2982393

2982395

2982400

2982402

2982405

2982409

2982411

2982413

2982417

2982418

2999263

2999271

3407336

3407359

3407360

3407362

3407363

3407365

3407367

34791_at

6950

8130567

A_23_P122782

A_33_P3349947

GE61593

GE86458

GO:0000003

GO:0000166

GO:0000242

GO:0000792

GO:0001669

GO:0002199

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005694

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006259

GO:0006457

GO:0006810

GO:0007021

GO:0007165

GO:0007339

GO:0008150

GO:0008219

GO:0009058

GO:0015031

GO:0016887

GO:0019899

GO:0022607

GO:0031410

GO:0031625

GO:0032212

GO:0032991

GO:0034641

GO:0035722

GO:0042592

GO:0043167

GO:0043226

GO:0044053

GO:0044183

GO:0044297

GO:0044403

GO:0050821

GO:0051082

GO:0051276

GO:0051973

GO:0065003

GO:0070062

GO:0090666

GO:1901998

GO:1904851

GO:1904871

GO:1904874

GO:2000109

HMNXSV003013792

Hs.278544.2.A1_3p_s_at

ILMN_1660661

ILMN_1776347

ILMN_2313434

PH_hs_0000453

TC06002277.hg

X52882_at

g12653758_3p_s_at

Participates

as a component of

as an output of

Expression of TCP1 (Homo sapiens)

Inferred To

CCT1 [cytosol] (Drosophila melanogaster)

Tcp1 [cytosol] (Mus musculus)

Tcp1 [cytosol] (Rattus norvegicus)

cct1 [cytosol] (Schizosaccharomyces pombe)

cct-1 [cytosol] (Caenorhabditis elegans)

tcp1 [cytosol] (Danio rerio)

tcp1 [cytosol] (Dictyostelium discoideum)

TCP1 [cytosol] (Canis familiaris)

TCP1 [cytosol] (Gallus gallus)

TCP1 [cytosol] (Plasmodium falciparum)

TCP1 [cytosol] (Saccharomyces cerevisiae)

TCP1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_110379.2

OpenTargets

ENSG00000120438

GeneCards

P17987

HPA

ENSG00000120438-TCP1

Ensembl

ENSP00000317334, ENST00000321394, ENSG00000120438

PRO

P17987

Pharos - Targets

P17987

GlyGen

P17987

PDB

6QB8, 6NRB, 6NR8, 6NRA, 7LUM, 6NRC, 6NR9, 7LUP, 6NRD

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978)	0.69	4
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.688	3
UniProt:P83110-2 HTRA3			0.644	7
UniProt:P78380 OLR1	3	OLR1 [tertiary granule membrane] (R-HSA-6800883) OLR1 [plasma membrane] (R-HSA-203139) OLR1 [specific granule membrane] (R-HSA-6799518)	0.644	5
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.643	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	4
UniProt:P60510 PPP4C	1	PPP4C [nucleoplasm] (R-HSA-5687750)	0.643	3
UniProt:Q13033 STRN3			0.643	3
UniProt:P83110-1 HTRA3			0.632	6
UniProt:P83105 HTRA4			0.621	7
UniProt:P61962 DCAF7	2	Unfolded DCAF7 [cytosol] (R-HSA-6813821) DCAF7 [nucleoplasm] (R-HSA-8863312)	0.615	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.597	4
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.564	2
UniProt:P50990 CCT8	5	CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [cytosol] (R-HSA-390449)	0.564	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.564	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.564	2
UniProt:O43439 MTG8R			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q9Y2Y0 ARL2BP	2	ARL2BP [cytosol] (R-HSA-5215982) ARL2BP [mitochondrial matrix] (R-HSA-5250220)	0.556	3
UniProt:P83110 HTRA3			0.537	5
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.527	2
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.527	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	2
UniProt:P23258 TUBG1	1	TUBG1 [cytosol] (R-HSA-379269)	0.527	2
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805)	0.527	4
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064)	0.527	2
UniProt:Q9BXA6 TSSK6			0.527	2
UniProt:P78318 IGBP1			0.527	2
UniProt:Q9Y2T4 2ABG			0.527	2
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342-PTK6 [cytosol] (R-HSA-8848007) PTK6 [cytosol] (R-HSA-8848000)	0.527	3
UniProt:P52333 JAK3	6	p-Y980 JAK3 [cytosol] (R-HSA-9701438) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) JAK3 [endosome] (R-HSA-8983184) p-JAK3 [cytosol] (R-HSA-8982856) p-Y-JAK3 [cytosol] (R-HSA-9006854) JAK3 [cytosol] (R-HSA-451893)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:Q8NBT0 POC1A			0.483	2
UniProt:Q00005 2ABB			0.462	3
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.462	2

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